ID   PGAP2_DANRE             Reviewed;         231 AA.
AC   Q5BL33;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Post-GPI attachment to proteins factor 2;
DE   AltName: Full=FGF receptor-activating protein 1;
GN   Name=pgap2; Synonyms=frag1; ORFNames=zgc:101568;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the lipid remodeling steps of GPI-anchor
CC       maturation. Required for stable expression of GPI-anchored proteins at
CC       the cell surface (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PGAP2 family. {ECO:0000305}.
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DR   EMBL; BC090817; AAH90817.1; -; mRNA.
DR   RefSeq; NP_001013562.1; NM_001013544.2.
DR   AlphaFoldDB; Q5BL33; -.
DR   STRING; 7955.ENSDARP00000065502; -.
DR   PaxDb; Q5BL33; -.
DR   GeneID; 541417; -.
DR   KEGG; dre:541417; -.
DR   CTD; 27315; -.
DR   ZFIN; ZDB-GENE-050320-119; pgap2.
DR   eggNOG; KOG3979; Eukaryota.
DR   InParanoid; Q5BL33; -.
DR   PhylomeDB; Q5BL33; -.
DR   PRO; PR:Q5BL33; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR   InterPro; IPR039545; PGAP2.
DR   PANTHER; PTHR12892; PTHR12892; 1.
DR   Pfam; PF10277; Frag1; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Golgi apparatus; GPI-anchor biosynthesis; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..231
FT                   /note="Post-GPI attachment to proteins factor 2"
FT                   /id="PRO_0000326097"
FT   TOPO_DOM        1..22
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        44..78
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        100..110
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        132..146
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        168..179
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        201..231
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   231 AA;  26490 MW;  01CEDC69309EF331 CRC64;
     MQQVPYGSVD RDKPLIRVPF TRLAVITVCL PLLGLVACIV LAMLYHYNDA TYTHCQVPNY
     LPSISAAISL TPERYIWRFS IGLHSAPRFL VAAAYLSFYR GRFSRRLTEQ LLSGFTFLLA
     LSENVGLLLL TYVSSTETYS VHKSGFILFI GSSLFHMLCT CKLWSLIVKY SISSEEMMSY
     WFKLRLFLFN GGCCVLAVYF YRRHNTYCEE GITHASRCVS IWWCCPTWPS T