PGAP2_XENLA
ID PGAP2_XENLA Reviewed; 254 AA.
AC Q5M9A7;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 48.
DE RecName: Full=Post-GPI attachment to proteins factor 2;
GN Name=pgap2;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the lipid remodeling steps of GPI-anchor
CC maturation. Required for stable expression of GPI-anchored proteins at
CC the cell surface (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PGAP2 family. {ECO:0000305}.
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DR EMBL; BC087380; AAH87380.1; -; mRNA.
DR RefSeq; NP_001088840.1; NM_001095371.1.
DR AlphaFoldDB; Q5M9A7; -.
DR DNASU; 496149; -.
DR GeneID; 496149; -.
DR KEGG; xla:496149; -.
DR CTD; 496149; -.
DR Xenbase; XB-GENE-6252506; pgap2.L.
DR OrthoDB; 1166083at2759; -.
DR Proteomes; UP000186698; Chromosome 2L.
DR Bgee; 496149; Expressed in testis and 19 other tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; ISS:UniProtKB.
DR InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR InterPro; IPR039545; PGAP2.
DR PANTHER; PTHR12892; PTHR12892; 1.
DR Pfam; PF10277; Frag1; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Golgi apparatus; GPI-anchor biosynthesis; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..254
FT /note="Post-GPI attachment to proteins factor 2"
FT /id="PRO_0000326098"
FT TOPO_DOM 1..24
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..113
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..186
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..210
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 232..254
FT /note="Lumenal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 254 AA; 29553 MW; DB5EEE07D51BD13D CRC64;
MVPISMAPDR GANSLVSLRF TTFAVSTVCL PLFAFLFCIV WSLLFNFSET TETHCHVPNY
LPSVSAAIGG ETPQRYLWRL CIGLHSAPRF LVAMAYLKYY QGTPCSNPYY PRLCHINFLL
NSCEIFFLML LTYVSSSENH EVHKLGFMSF MFFSLGYMFV TCTLWRMTRK WSGSPEERTS
YAWKKRLFGF YLLMFLASIV VYIWHNMYCE PGVYTLFAFL EYLVVLSNMA FHMTAWWDFG
NKELMICSPG DKRI