ID   PGAP2_XENTR             Reviewed;         252 AA.
AC   A8KBG2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Post-GPI attachment to proteins factor 2;
GN   Name=pgap2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the lipid remodeling steps of GPI-anchor
CC       maturation. Required for stable expression of GPI-anchored proteins at
CC       the cell surface (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PGAP2 family. {ECO:0000305}.
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DR   EMBL; BC154099; AAI54100.1; -; mRNA.
DR   RefSeq; NP_001106477.1; NM_001113006.1.
DR   AlphaFoldDB; A8KBG2; -.
DR   GeneID; 100127662; -.
DR   KEGG; xtr:100127662; -.
DR   CTD; 27315; -.
DR   Xenbase; XB-GENE-6454013; pgap2.
DR   InParanoid; A8KBG2; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR   InterPro; IPR039545; PGAP2.
DR   PANTHER; PTHR12892; PTHR12892; 1.
DR   Pfam; PF10277; Frag1; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Golgi apparatus; GPI-anchor biosynthesis; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..252
FT                   /note="Post-GPI attachment to proteins factor 2"
FT                   /id="PRO_0000326099"
FT   TOPO_DOM        1..22
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        44..77
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..111
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        133..142
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        164..184
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        206..208
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        230..252
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   252 AA;  28821 MW;  44320DC7BB806000 CRC64;
     MVPVGPERGA NSLFSLRFTT FAVGTVSLPL FAFLFCIVWS LLFNFSETTA THCHVPNYLP
     SVSAAIGGET PQRYIWRLCI GLHSAPRFLV GVAYLHYYQG TPCSSPAYPR LCHLNFLLNC
     CEIFFLILLT YVSSSENYEV HKLGFMAFML FSVGYMFVTC SLWRVARKGS GSLEERTSYA
     WKKRLFGFYL LMFLSSILVY IWHNMYCEAG VYTVFALLEY LVVLSNMGFH MTAWWDFGNK
     ELMICSPGDK RI