ID   PGAP3_DANRE             Reviewed;         316 AA.
AC   A8WFS8;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Post-GPI attachment to proteins factor 3;
DE   AltName: Full=PER1-like domain-containing protein 1;
DE   Flags: Precursor;
GN   Name=pgap3; Synonyms=perld1; ORFNames=zgc:171485;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the lipid remodeling steps of GPI-anchor
CC       maturation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PGAP3 family. {ECO:0000305}.
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DR   EMBL; BC154443; AAI54444.1; -; mRNA.
DR   RefSeq; NP_001108063.1; NM_001114591.1.
DR   AlphaFoldDB; A8WFS8; -.
DR   STRING; 7955.ENSDARP00000126623; -.
DR   PaxDb; A8WFS8; -.
DR   PRIDE; A8WFS8; -.
DR   GeneID; 100136873; -.
DR   KEGG; dre:100136873; -.
DR   CTD; 93210; -.
DR   ZFIN; ZDB-GENE-080204-27; pgap3.
DR   eggNOG; KOG2970; Eukaryota.
DR   InParanoid; A8WFS8; -.
DR   OrthoDB; 828384at2759; -.
DR   PhylomeDB; A8WFS8; -.
DR   PRO; PR:A8WFS8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031227; C:intrinsic component of endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; ISS:UniProtKB.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006505; P:GPI anchor metabolic process; ISS:UniProtKB.
DR   InterPro; IPR007217; Per1-like.
DR   PANTHER; PTHR13148; PTHR13148; 1.
DR   Pfam; PF04080; Per1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Golgi apparatus; GPI-anchor biosynthesis; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..316
FT                   /note="Post-GPI attachment to proteins factor 3"
FT                   /id="PRO_0000339358"
FT   TOPO_DOM        20..97
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..131
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        153..165
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        187..194
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        216..220
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        242..254
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        276..278
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        300..316
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        36
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   316 AA;  36062 MW;  80FF80488F5F628D CRC64;
     MFLAAAAFLL SAPASASQGD KEPVYRDCVK HCVRANCTGA RLRGFQSTQP PYMALTGWTC
     RDDCRYQCMW TTVGLYQAEG YSIPQFHGKW PFARFLCFEE PASALASLLN GLACLLMLLR
     YRSAVPCQSP MYHTITAFSL VSLNAWFWST VFHTRDTYLT EKMDYFCASA VILYSIYLCC
     VRTLGLRRPA ISSMVGVLLI LAFTSHVSYL TFVSFDYGYN MAANASIGII NLLWWLCWCW
     LNRRILPYWW RCGMVVLLLH GLALLELLDF PPLFWVLDAH AVWHLSTVPV HFLFYSFLID
     DSLHLLNTEK PGVKLD