ID   PGAP3_XENLA             Reviewed;         317 AA.
AC   Q68EV0;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Post-GPI attachment to proteins factor 3;
DE   AltName: Full=PER1-like domain-containing protein 1;
DE   Flags: Precursor;
GN   Name=pgap3; Synonyms=perld1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the lipid remodeling steps of GPI-anchor
CC       maturation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PGAP3 family. {ECO:0000305}.
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DR   EMBL; BC080100; AAH80100.1; -; mRNA.
DR   RefSeq; NP_001087556.1; NM_001094087.1.
DR   AlphaFoldDB; Q68EV0; -.
DR   DNASU; 447380; -.
DR   GeneID; 447380; -.
DR   KEGG; xla:447380; -.
DR   CTD; 447380; -.
DR   Xenbase; XB-GENE-947222; pgap3.L.
DR   OrthoDB; 828384at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 447380; Expressed in testis and 19 other tissues.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031227; C:intrinsic component of endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; ISS:UniProtKB.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006505; P:GPI anchor metabolic process; ISS:UniProtKB.
DR   InterPro; IPR007217; Per1-like.
DR   PANTHER; PTHR13148; PTHR13148; 1.
DR   Pfam; PF04080; Per1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Golgi apparatus; GPI-anchor biosynthesis; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..317
FT                   /note="Post-GPI attachment to proteins factor 3"
FT                   /id="PRO_0000339359"
FT   TOPO_DOM        19..93
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..132
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        154..163
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        181..189
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        211..219
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        241..251
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        273
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..317
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        35
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   317 AA;  37085 MW;  B689D53CB7F82041 CRC64;
     MAPFLVLFLA GVVSASRGDR EPVYRDCVTV CDQNNCTGFR LRDFRAQQPL YMRLTGWTCL
     DDCRYKCMWY TVSLYLKEGH EVPQFHGKWP FSRFLFFQEP ASALASFLNG VASLLMLFRY
     RSSVPSSCQM YRTCLAFSMV SVNAWFWSTI FHTRDTALTE KMDYFCASSV ILHSIYLCCM
     RTFGLQYPSI ANAFGAFLVL LFACHISYLT LGRFDYSYNM AANTSFGIVN LMWWLAWCMW
     RRFHQPYLWK CVLVVVLLQS LALLELLDFP PVMWILDAHA LWHFSTIPLH FLFYSFLRDD
     SLYLLKVNHD DDIPKLD