ID   PGAP3_XENTR             Reviewed;         316 AA.
AC   Q0VFE3;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Post-GPI attachment to proteins factor 3;
DE   AltName: Full=PER1-like domain-containing protein 1;
DE   Flags: Precursor;
GN   Name=pgap3; Synonyms=perld1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the lipid remodeling steps of GPI-anchor
CC       maturation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PGAP3 family. {ECO:0000305}.
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DR   EMBL; BC118861; AAI18862.1; -; mRNA.
DR   RefSeq; NP_001072247.1; NM_001078779.1.
DR   AlphaFoldDB; Q0VFE3; -.
DR   STRING; 8364.ENSXETP00000033156; -.
DR   PaxDb; Q0VFE3; -.
DR   DNASU; 779696; -.
DR   Ensembl; ENSXETT00000033156; ENSXETP00000033156; ENSXETG00000015142.
DR   GeneID; 779696; -.
DR   KEGG; xtr:779696; -.
DR   CTD; 93210; -.
DR   Xenbase; XB-GENE-947217; pgap3.
DR   eggNOG; KOG2970; Eukaryota.
DR   HOGENOM; CLU_032917_1_0_1; -.
DR   InParanoid; Q0VFE3; -.
DR   OrthoDB; 828384at2759; -.
DR   PhylomeDB; Q0VFE3; -.
DR   Proteomes; UP000008143; Chromosome 10.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000015142; Expressed in skeletal muscle tissue and 12 other tissues.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031227; C:intrinsic component of endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; ISS:UniProtKB.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006505; P:GPI anchor metabolic process; ISS:UniProtKB.
DR   InterPro; IPR007217; Per1-like.
DR   PANTHER; PTHR13148; PTHR13148; 1.
DR   Pfam; PF04080; Per1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Golgi apparatus; GPI-anchor biosynthesis; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..316
FT                   /note="Post-GPI attachment to proteins factor 3"
FT                   /id="PRO_0000339360"
FT   TOPO_DOM        19..93
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..132
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        154..163
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        181..182
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        204..218
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        240..251
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        273
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..316
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        35
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   316 AA;  36736 MW;  DFAB1E412C63F3C1 CRC64;
     MAPFLVLFLA GVVAASRGDR EPVYRDCVTL CERNNCTGSR LTDFRAEQPL YMRVTGWTCL
     DDCRYQCMWY TVSLYLKEGH EVPQFHGKWP FSRFLFFQEP ASALASFLNG VASLLMLLRY
     RSSVPSSCQM YRTCLAFSMV SVNAWFWSTI FHTRDTALTE KMDYFCASSV ILHSIYLCCM
     RTFGLQYPSI ANGFGAFLVL LFACHVSYLT LGRFDYSYNM AANTGFGVLN LMWWLAWCFR
     RRFHQPYLWK CVLVVISLQS LALLELLDFP PVMWILDAHA LWHFSTVPLH FLFYSFLKDD
     SLYLLKINHD DIPKLD