ID   PGBA_HELPJ              Reviewed;         450 AA.
AC   Q9ZLW8;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Plasminogen-binding protein PgbA;
GN   Name=pgbA; OrderedLocusNames=jhp_0458;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- FUNCTION: Binds plasminogen, specifically, and in a concentration and
CC       lysine-dependent manner. Plasminogen is the precursor of plasmin, a
CC       serine protease that cleaves fibrin, fibronectin, laminin and
CC       vitronectin. Acquisition of plasminogen/plasmin could enable H.pylori
CC       to degrade host components (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000305}. Note=The plasminogen-
CC       binding region is localized on the surface the bacterium.
CC       {ECO:0000305}.
CC   -!- MISCELLANEOUS: Plasminogen bound to PgbA is capable of being converted
CC       to functionally active plasmin. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE001439; AAD06039.1; -; Genomic_DNA.
DR   PIR; G71928; G71928.
DR   RefSeq; WP_000945055.1; NZ_CP011330.1.
DR   AlphaFoldDB; Q9ZLW8; -.
DR   SMR; Q9ZLW8; -.
DR   STRING; 85963.jhp_0458; -.
DR   PRIDE; Q9ZLW8; -.
DR   EnsemblBacteria; AAD06039; AAD06039; jhp_0458.
DR   KEGG; hpj:jhp_0458; -.
DR   PATRIC; fig|85963.30.peg.546; -.
DR   OMA; HLPTPRM; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   InterPro; IPR032737; PGBA_C.
DR   InterPro; IPR029276; PgbA_N.
DR   Pfam; PF15437; PGBA_C; 2.
DR   Pfam; PF15436; PGBA_N; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..450
FT                   /note="Plasminogen-binding protein PgbA"
FT                   /id="PRO_0000058350"
FT   REGION          262..450
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        286..365
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        366..384
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        385..450
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   450 AA;  52221 MW;  48D6D921A08C2359 CRC64;
     MLRLLIGLLL MSFISLQSAS WQEPLRVSIE FVDLPKKIIR FPAHDLKVGE FGFVVTKLSD
     YEIVNSEVVI IAVENGVATA KFKAFESMKQ SHLPTPRMVA KKGDLVYFRQ FNNQAFLIAP
     NDELYEQIRA TNTDINFISS DLLVTFLNGF DPKIANLRKA CNVYSVGVIY IVTTNTLNIL
     SCESFEILEK RELDTSGVTK TSTPFFSRVE GIDAGTLGKL FSGSQSKNYF AYYDALVKKE
     KRKEVRIEKK EERIDARENK REIKQEAIKE PKKANQGTEN APTLEEKNYQ KAERKFDAKE
     ERRRSRDERK KTKATKKAME FEEREKEHDE RDEKETEERR KALEMDKGNE KVNAKENERE
     INQESANEPS SENNATLKDT ENTSVLKESA AKKEAPKPSS KEEKRRLKEE KKKAKAEQRA
     REFEQRAREH QERDEKELEE RRKALEMNKK