PGBA_HELPY
ID PGBA_HELPY Reviewed; 452 AA.
AC O25249; Q70SU1;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Plasminogen-binding protein PgbA;
GN Name=pgbA; OrderedLocusNames=HP_0508;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PLASMINOGEN-BINDING ACTIVITY.
RC STRAIN=ATCC 700392 / 26695, and DSM 4867 / CCUG 17874 / NCTC 11638;
RX PubMed=14769936; DOI=10.1073/pnas.0307329101;
RA Joensson K., Guo B.P., Monstein H.J., Mekalanos J.J., Kronvall G.;
RT "Molecular cloning and characterization of two Helicobacter pylori genes
RT coding for plasminogen-binding proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:1852-1857(2004).
CC -!- FUNCTION: Binds plasminogen, specifically, and in a concentration and
CC lysine-dependent manner. Plasminogen is the precursor of plasmin, a
CC serine protease that cleaves fibrin, fibronectin, laminin and
CC vitronectin. Acquisition of plasminogen/plasmin could enable H.pylori
CC to degrade host components.
CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000305}. Note=The plasminogen-
CC binding region is localized on the surface the bacterium.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: Plasminogen bound to PgbA is capable of being converted
CC to functionally active plasmin.
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DR EMBL; AE000511; AAD07578.1; -; Genomic_DNA.
DR EMBL; AJ550456; CAD79440.1; -; Genomic_DNA.
DR PIR; D64583; D64583.
DR RefSeq; NP_207305.1; NC_000915.1.
DR RefSeq; WP_000945103.1; NC_018939.1.
DR AlphaFoldDB; O25249; -.
DR STRING; 85962.C694_02610; -.
DR PaxDb; O25249; -.
DR EnsemblBacteria; AAD07578; AAD07578; HP_0508.
DR KEGG; hpy:HP_0508; -.
DR PATRIC; fig|85962.47.peg.546; -.
DR OMA; HLPTPRM; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR InterPro; IPR032737; PGBA_C.
DR InterPro; IPR029276; PgbA_N.
DR Pfam; PF15437; PGBA_C; 2.
DR Pfam; PF15436; PGBA_N; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..452
FT /note="Plasminogen-binding protein PgbA"
FT /id="PRO_0000058351"
FT REGION 265..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..370
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 91
FT /note="R -> S (in strain: CCUG 17874)"
FT VARIANT 138
FT /note="Missing (in strain: CCUG 17874)"
FT VARIANT 199
FT /note="T -> I (in strain: CCUG 17874)"
FT VARIANT 252
FT /note="E -> G (in strain: CCUG 17874)"
FT VARIANT 279
FT /note="Q -> E (in strain: CCUG 17874)"
FT VARIANT 349
FT /note="D -> N (in strain: CCUG 17874)"
FT VARIANT 350..352
FT /note="Missing (in strain: CCUG 17874)"
FT VARIANT 354
FT /note="R -> K (in strain: CCUG 17874)"
FT VARIANT 356..357
FT /note="KP -> NA (in strain: CCUG 17874)"
FT VARIANT 373..374
FT /note="SD -> DN (in strain: CCUG 17874)"
FT VARIANT 394
FT /note="Q -> S (in strain: CCUG 17874)"
FT VARIANT 398
FT /note="N -> K (in strain: CCUG 17874)"
FT VARIANT 449..450
FT /note="AG -> MN (in strain: CCUG 17874)"
SQ SEQUENCE 452 AA; 52656 MW; E2F88D85EC9EDB92 CRC64;
MLRLLIGLLL MSFISLQSAS WQEPLRVSIE FVDLPKKIIR FPAHDLQVGE FGFVVTKLSD
YEIVNSEVVI IAVENGVATA KFRAFESMKQ RHLPTPRMVA RKGDLVYFRQ FNNQAFLIAP
NDELYEQIRA TNTDINFISS DLLVTFLNGF DPKIANLRKA CNVYSVGVIY IVTTNTLNIL
SCESFEILEK RELDTSGVTK TSTPFFSRVE GIDAGTLGKL FSGSQSKNYF AYYDALVKKE
KRKEVRIKKR EEKIDSREIK REIKQEAIKE PKKANQGTQN APTLEEKNYQ KAERKLDAKE
ERRYLRDERK KAKATKKAME FEEREKEHDE RDEQETEGRR KALEMDKGDK KEERVKPKEN
EREIKQEAIK EPSDGNNATQ QGEKQNAPKE NNAQKEENKP NSKEEKRRLK EEKKKAKAEQ
RAREFEQRAR EHQERDEKEL EERRKALEAG KK
