ID   PGBB_HELPJ              Reviewed;         541 AA.
AC   Q9ZKY5;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Plasminogen-binding protein PgbB;
GN   Name=pgbB; OrderedLocusNames=jhp_0797;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- FUNCTION: Binds plasminogen, specifically, and in a concentration and
CC       lysine-dependent manner. Plasminogen is the precursor of plasmin, a
CC       serine protease that cleaves fibrin, fibronectin, laminin and
CC       vitronectin. Acquisition of plasminogen/plasmin could enable H.pylori
CC       to degrade host components (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000305}. Note=The plasminogen-
CC       binding region is localized on the surface the bacterium.
CC       {ECO:0000305}.
CC   -!- MISCELLANEOUS: Plasminogen bound to PgbB is capable of being converted
CC       to functionally active plasmin. {ECO:0000250}.
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DR   EMBL; AE001439; AAD06373.1; -; Genomic_DNA.
DR   PIR; H71887; H71887.
DR   RefSeq; WP_001039534.1; NZ_CP011330.1.
DR   AlphaFoldDB; Q9ZKY5; -.
DR   SMR; Q9ZKY5; -.
DR   STRING; 85963.jhp_0797; -.
DR   PRIDE; Q9ZKY5; -.
DR   EnsemblBacteria; AAD06373; AAD06373; jhp_0797.
DR   KEGG; hpj:jhp_0797; -.
DR   PATRIC; fig|85963.30.peg.175; -.
DR   eggNOG; ENOG50316V3; Bacteria.
DR   OMA; NESQGFF; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR032737; PGBA_C.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF15437; PGBA_C; 1.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..541
FT                   /note="Plasminogen-binding protein PgbB"
FT                   /id="PRO_0000058352"
FT   REGION          420..541
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        420..454
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        455..476
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        477..541
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   541 AA;  61715 MW;  3232E0A398B69B1E CRC64;
     MNKPFLILLI ALIAFSGCNM RKYFKPAKHQ IKGEAYFPNH LQESIVSSNR YGAILKNGAV
     IGDKGLTQLR IGKNFNYESS FLNESQGFFI LAQDCLNKID KKTSKSRAAK TEETELKLKG
     VEAEVQDKVC HQVELISNNP NASQQSIVIP LETFALSASV KGNLLAVVLA DNSANLYDIT
     SQKLLFSEKG SPSTTINSLM AMPIFMDTVV VFPMLDGRLL VVDYVHGNPT PIRNIVISSD
     KFFNNITYLI VDGNNMIAST GKRILSVVSG QEFNYDGDIV DLLYDKGTLY VLTLDGQILQ
     MDKSLRELNS VKLPFASLNT IVLNNNKLYS LEKRGYVIEV DLNDFDSYNV YKTPTIGSFK
     FFSSNRLDKG VFYDKNRVYY DRYYLDYNDF KPKLYPHAAE FKTSQKGEKG NAPIYLQERH
     KAKENKQPLE ENKVKPRNSG FEEEEVKTRR PEPTKDQNNA IQQGETKNNE SKNTPISKEN
     AAKKEAPKPS SKEEKRRLKE EKKKAKAEQR AREFEQRARE HQERDEKELE ERRKALEMNK
     K