ID   PGBB_HELPY              Reviewed;         542 AA.
AC   O25534;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Plasminogen-binding protein PgbB;
GN   Name=pgbB; OrderedLocusNames=HP_0863;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
RN   [2]
RP   PLASMINOGEN-BINDING ACTIVITY.
RC   STRAIN=ATCC 700392 / 26695, and DSM 4867 / CCUG 17874 / NCTC 11638;
RX   PubMed=14769936; DOI=10.1073/pnas.0307329101;
RA   Joensson K., Guo B.P., Monstein H.J., Mekalanos J.J., Kronvall G.;
RT   "Molecular cloning and characterization of two Helicobacter pylori genes
RT   coding for plasminogen-binding proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:1852-1857(2004).
CC   -!- FUNCTION: Binds plasminogen, specifically, and in a concentration and
CC       lysine-dependent manner. Plasminogen is the precursor of plasmin, a
CC       serine protease that cleaves fibrin, fibronectin, laminin and
CC       vitronectin. Acquisition of plasminogen/plasmin could enable H.pylori
CC       to degrade host components.
CC   -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000305}. Note=The plasminogen-
CC       binding region is localized on the surface the bacterium.
CC       {ECO:0000305}.
CC   -!- MISCELLANEOUS: Plasminogen bound to PgbB is capable of being converted
CC       to functionally active plasmin.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000511; AAD07917.1; -; Genomic_DNA.
DR   PIR; G64627; G64627.
DR   RefSeq; NP_207657.1; NC_000915.1.
DR   RefSeq; WP_001039566.1; NC_018939.1.
DR   AlphaFoldDB; O25534; -.
DR   STRING; 85962.C694_04420; -.
DR   PaxDb; O25534; -.
DR   EnsemblBacteria; AAD07917; AAD07917; HP_0863.
DR   KEGG; hpy:HP_0863; -.
DR   PATRIC; fig|85962.47.peg.917; -.
DR   eggNOG; ENOG50316V3; Bacteria.
DR   OMA; NESQGFF; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR032737; PGBA_C.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF15437; PGBA_C; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..542
FT                   /note="Plasminogen-binding protein PgbB"
FT                   /id="PRO_0000058353"
FT   REGION          399..542
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        414..455
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..476
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        478..542
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   542 AA;  61900 MW;  E77A4EF68A04ECED CRC64;
     MNKPFLILLI ALIVFSGCNM RKYFKPAKHQ IKGEAYFPNH LQESIVSSNR YGAILKNGAV
     IGDKGLTQLR IGKNFNYESS FLNESQGFFI LAQDCLNKID KKTNKSKVAK TEETELKLKG
     VEAEVQDKVC HQVELISNNP NASQQSIVIP LETFALSASV KGNLLAVVLA DNSANLYDIT
     SQKLLFSEKG SPSTTINSLM AMPIFMDTVV VFPMLDGRLL VVDYVHGNPT PIRNIVISSD
     KFFNNITYLI VDGNNMIAST GKRILSVVSG QEFNYDGDIV DLLYDKGTLY VLTLDGQILQ
     MDKSLRELNS VKLPSSLNTI VLNHNKLYSL EKRGYVIEVD LNDFDSYNVY KTPTIGSFKF
     FSSNRLDKGV FYDKNRVYYD RYYLDYNDFK PKLYPVVEKS ASKKSQKGEK GNAPIYLQER
     HKAKENKQPL EENKVKPRNS GFEEEEVKTR RPEPIRDQNN ATQQGETKNN ESKNAPVLKE
     NAAKKEVPKP NSKEEKRRLK EEKKKAKAEQ RAREFEQRAR EHQERDEKEL EERRKALEMN
     KK