PGBD1_HUMAN
ID PGBD1_HUMAN Reviewed; 809 AA.
AC Q96JS3; Q53F43; Q6NTF5; Q8WWS4;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=PiggyBac transposable element-derived protein 1;
DE AltName: Full=Cerebral protein 4;
GN Name=PGBD1; ORFNames=hucep-4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Yoshimoto M., Yazaki M., Takayama K., Matsumoto K.;
RT "Biological functions of a novel human gene, hucep-4, which is specifically
RT expressed in the central nervous system.";
RL Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-218, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- INTERACTION:
CC Q96JS3; P50222: MEOX2; NbExp=6; IntAct=EBI-10290053, EBI-748397;
CC Q96JS3; P22736: NR4A1; NbExp=3; IntAct=EBI-10290053, EBI-721550;
CC Q96JS3; P22736-2: NR4A1; NbExp=3; IntAct=EBI-10290053, EBI-12697871;
CC Q96JS3; Q96JS3: PGBD1; NbExp=5; IntAct=EBI-10290053, EBI-10290053;
CC Q96JS3; P57086: SCAND1; NbExp=11; IntAct=EBI-10290053, EBI-745846;
CC Q96JS3; Q12933: TRAF2; NbExp=7; IntAct=EBI-10290053, EBI-355744;
CC Q96JS3; Q969J2: ZKSCAN4; NbExp=4; IntAct=EBI-10290053, EBI-2818641;
CC Q96JS3; Q9P0L1-2: ZKSCAN7; NbExp=3; IntAct=EBI-10290053, EBI-10698225;
CC Q96JS3; P17028: ZNF24; NbExp=8; IntAct=EBI-10290053, EBI-707773;
CC Q96JS3; Q9NWS9: ZNF446; NbExp=5; IntAct=EBI-10290053, EBI-3925851;
CC Q96JS3; Q9NWS9-2: ZNF446; NbExp=6; IntAct=EBI-10290053, EBI-740232;
CC Q96JS3; Q96IT1: ZNF496; NbExp=6; IntAct=EBI-10290053, EBI-743906;
CC Q96JS3; O43309: ZSCAN12; NbExp=3; IntAct=EBI-10290053, EBI-1210440;
CC Q96JS3; Q8TBC5: ZSCAN18; NbExp=3; IntAct=EBI-10290053, EBI-3919096;
CC Q96JS3; P10073: ZSCAN22; NbExp=9; IntAct=EBI-10290053, EBI-10178224;
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DR EMBL; D88259; BAB46919.1; -; mRNA.
DR EMBL; AK223446; BAD97166.1; -; mRNA.
DR EMBL; AL021997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069033; AAH69033.1; ALT_TERM; mRNA.
DR EMBL; BC128585; AAI28586.1; -; mRNA.
DR CCDS; CCDS4648.1; -.
DR RefSeq; NP_001171672.1; NM_001184743.1.
DR RefSeq; NP_115896.1; NM_032507.3.
DR RefSeq; XP_016866850.1; XM_017011361.1.
DR AlphaFoldDB; Q96JS3; -.
DR SMR; Q96JS3; -.
DR BioGRID; 124132; 30.
DR IntAct; Q96JS3; 26.
DR STRING; 9606.ENSP00000259883; -.
DR iPTMnet; Q96JS3; -.
DR PhosphoSitePlus; Q96JS3; -.
DR BioMuta; PGBD1; -.
DR DMDM; 74751967; -.
DR EPD; Q96JS3; -.
DR MassIVE; Q96JS3; -.
DR MaxQB; Q96JS3; -.
DR PaxDb; Q96JS3; -.
DR PeptideAtlas; Q96JS3; -.
DR PRIDE; Q96JS3; -.
DR ProteomicsDB; 77007; -.
DR ABCD; Q96JS3; 2 sequenced antibodies.
DR Antibodypedia; 1792; 260 antibodies from 32 providers.
DR DNASU; 84547; -.
DR Ensembl; ENST00000259883.3; ENSP00000259883.3; ENSG00000137338.6.
DR Ensembl; ENST00000682144.1; ENSP00000506997.1; ENSG00000137338.6.
DR GeneID; 84547; -.
DR KEGG; hsa:84547; -.
DR MANE-Select; ENST00000682144.1; ENSP00000506997.1; NM_032507.4; NP_115896.1.
DR UCSC; uc003nkz.4; human.
DR CTD; 84547; -.
DR DisGeNET; 84547; -.
DR GeneCards; PGBD1; -.
DR HGNC; HGNC:19398; PGBD1.
DR HPA; ENSG00000137338; Low tissue specificity.
DR neXtProt; NX_Q96JS3; -.
DR OpenTargets; ENSG00000137338; -.
DR PharmGKB; PA134919893; -.
DR VEuPathDB; HostDB:ENSG00000137338; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163016; -.
DR HOGENOM; CLU_357756_0_0_1; -.
DR InParanoid; Q96JS3; -.
DR OMA; HMKKMKR; -.
DR OrthoDB; 279711at2759; -.
DR PhylomeDB; Q96JS3; -.
DR TreeFam; TF328011; -.
DR PathwayCommons; Q96JS3; -.
DR SignaLink; Q96JS3; -.
DR BioGRID-ORCS; 84547; 7 hits in 1080 CRISPR screens.
DR GenomeRNAi; 84547; -.
DR Pharos; Q96JS3; Tbio.
DR PRO; PR:Q96JS3; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q96JS3; protein.
DR Bgee; ENSG00000137338; Expressed in cortical plate and 111 other tissues.
DR Genevisible; Q96JS3; HS.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR029526; PGBD.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR001190; SRCR.
DR Pfam; PF13843; DDE_Tnp_1_7; 1.
DR Pfam; PF02023; SCAN; 1.
DR SMART; SM00431; SCAN; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
PE 1: Evidence at protein level;
KW Isopeptide bond; Phosphoprotein; Reference proteome; Ubl conjugation.
FT CHAIN 1..809
FT /note="PiggyBac transposable element-derived protein 1"
FT /id="PRO_0000288052"
FT DOMAIN 44..126
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT REGION 170..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 360
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT CROSSLNK 218
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VARIANT 244
FT /note="G -> E (in dbSNP:rs3800324)"
FT /id="VAR_032384"
FT VARIANT 244
FT /note="G -> R (in dbSNP:rs3800324)"
FT /id="VAR_051273"
FT VARIANT 248
FT /note="Q -> E (in dbSNP:rs3800325)"
FT /id="VAR_032385"
FT VARIANT 256
FT /note="P -> L (in dbSNP:rs3800326)"
FT /id="VAR_032386"
FT VARIANT 398
FT /note="N -> S (in dbSNP:rs33932084)"
FT /id="VAR_032387"
FT VARIANT 592
FT /note="M -> I (in dbSNP:rs16893917)"
FT /id="VAR_032388"
FT VARIANT 678
FT /note="I -> V (in dbSNP:rs1997660)"
FT /id="VAR_032389"
FT VARIANT 806
FT /note="H -> D (in dbSNP:rs6456811)"
FT /id="VAR_032390"
FT CONFLICT 99
FT /note="E -> G (in Ref. 2; BAD97166)"
FT /evidence="ECO:0000305"
FT CONFLICT 493
FT /note="I -> V (in Ref. 2; BAD97166)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 809 AA; 92515 MW; B311C58D171ABF3E CRC64;
MYEALPGPAP ENEDGLVKVK EEDPTWEQVC NSQEGSSHTQ EICRLRFRHF CYQEAHGPQE
ALAQLRELCH QWLRPEMHTK EQIMELLVLE QFLTILPKEL QPCVKTYPLE SGEEAVTVLE
NLETGSGDTG QQASVYIQGQ DMHPMVAEYQ GVSLECQSLQ LLPGITTLKC EPPQRPQGNP
QEVSGPVPHG SAHLQEKNPR DKAVVPVFNP VRSQTLVKTE EETAQAVAAE KWSHLSLTRR
NLCGNSAQET VMSLSPMTEE IVTKDRLFKA KQETSEEMEQ SGEASGKPNR ECAPQIPCST
PIATERTVAH LNTLKDRHPG DLWARMHISS LEYAAGDITR KGRKKDKARV SELLQGLSFS
GDSDVEKDNE PEIQPAQKKL KVSCFPEKSW TKRDIKPNFP SWSALDSGLL NLKSEKLNPV
ELFELFFDDE TFNLIVNETN NYASQKNVSL EVTVQEMRCV FGVLLLSGFM RHPRREMYWE
VSDTDQNLVR DAIRRDRFEL IFSNLHFADN GHLDQKDKFT KLRPLIKQMN KNFLLYAPLE
EYYCFDKSMC ECFDSDQFLN GKPIRIGYKI WCGTTTQGYL VWFEPYQEES TMKVDEDPDL
GLGGNLVMNF ADVLLERGQY PYHLCFDSFF TSVKLLSALK KKGVRATGTI RENRTEKCPL
MNVEHMKKMK RGYFDFRIEE NNEIILCRWY GDGIISLCSN AVGIEPVNEV SCCDADNEEI
PQISQPSIVK VYDECKEGVA KMDQIISKYR VRIRSKKWYS ILVSYMIDVA MNNAWQLHRA
CNPGASLDPL DFRRFVAHFY LEHNAHLSD
