PGBD4_HUMAN
ID PGBD4_HUMAN Reviewed; 585 AA.
AC Q96DM1; A1L487; A8K0C6; Q8N9E8;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 3.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=PiggyBac transposable element-derived protein 4;
GN Name=PGBD4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Cerebellum, and Synovial cell;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04428.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK057200; BAB71379.1; -; mRNA.
DR EMBL; AK094816; BAC04428.1; ALT_INIT; mRNA.
DR EMBL; AK289491; BAF82180.1; -; mRNA.
DR EMBL; AC079203; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS10033.1; -.
DR RefSeq; NP_689808.2; NM_152595.4.
DR AlphaFoldDB; Q96DM1; -.
DR SMR; Q96DM1; -.
DR BioGRID; 127802; 2.
DR IntAct; Q96DM1; 1.
DR STRING; 9606.ENSP00000380872; -.
DR GlyGen; Q96DM1; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96DM1; -.
DR PhosphoSitePlus; Q96DM1; -.
DR BioMuta; PGBD4; -.
DR DMDM; 269849663; -.
DR EPD; Q96DM1; -.
DR MassIVE; Q96DM1; -.
DR PaxDb; Q96DM1; -.
DR PeptideAtlas; Q96DM1; -.
DR PRIDE; Q96DM1; -.
DR Antibodypedia; 51724; 34 antibodies from 13 providers.
DR DNASU; 161779; -.
DR Ensembl; ENST00000397766.4; ENSP00000380872.2; ENSG00000182405.6.
DR GeneID; 161779; -.
DR KEGG; hsa:161779; -.
DR MANE-Select; ENST00000397766.4; ENSP00000380872.2; NM_152595.5; NP_689808.2.
DR UCSC; uc001zho.4; human.
DR CTD; 161779; -.
DR DisGeNET; 161779; -.
DR GeneCards; PGBD4; -.
DR HGNC; HGNC:19401; PGBD4.
DR HPA; ENSG00000182405; Low tissue specificity.
DR neXtProt; NX_Q96DM1; -.
DR OpenTargets; ENSG00000182405; -.
DR PharmGKB; PA134885912; -.
DR VEuPathDB; HostDB:ENSG00000182405; -.
DR eggNOG; ENOG502QWHD; Eukaryota.
DR GeneTree; ENSGT00940000164464; -.
DR HOGENOM; CLU_013052_3_2_1; -.
DR InParanoid; Q96DM1; -.
DR OMA; DVKWFEI; -.
DR OrthoDB; 1139412at2759; -.
DR PhylomeDB; Q96DM1; -.
DR TreeFam; TF328011; -.
DR PathwayCommons; Q96DM1; -.
DR SignaLink; Q96DM1; -.
DR BioGRID-ORCS; 161779; 10 hits in 1079 CRISPR screens.
DR GenomeRNAi; 161779; -.
DR Pharos; Q96DM1; Tdark.
DR PRO; PR:Q96DM1; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q96DM1; protein.
DR Bgee; ENSG00000182405; Expressed in stromal cell of endometrium and 98 other tissues.
DR Genevisible; Q96DM1; HS.
DR InterPro; IPR029526; PGBD.
DR InterPro; IPR032718; PGBD4_C_Znf-ribbon.
DR Pfam; PF13843; DDE_Tnp_1_7; 1.
DR Pfam; PF13842; Tnp_zf-ribbon_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..585
FT /note="PiggyBac transposable element-derived protein 4"
FT /id="PRO_0000288055"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..42
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 113
FT /note="T -> I (in Ref. 1; BAF82180)"
FT /evidence="ECO:0000305"
FT CONFLICT 473
FT /note="K -> E (in Ref. 1; BAB71379)"
FT /evidence="ECO:0000305"
FT CONFLICT 554
FT /note="K -> R (in Ref. 1; BAB71379)"
FT /evidence="ECO:0000305"
FT CONFLICT 556
FT /note="R -> Q (in Ref. 1; BAF82180)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 585 AA; 67004 MW; 3920530DBF745E0F CRC64;
MSNPRKRSIP MRDSNTGLEQ LLAEDSFDES DFSEIDDSDN FSDSALEADK IRPLSHLESD
GKSSTSSDSG RSMKWSARAM IPRQRYDFTG TPGRKVDVSD ITDPLQYFEL FFTEELVSKI
TRETNAQAAL LASKPPGPKG FSRMDKWKDT DNDELKVFFA VMLLQGIVQK PELEMFWSTR
PLLDTPYLRQ IMTGERFLLL FRCLHFVNNS SISAGQSKAQ ISLQKIKPVF DFLVNKFSTV
YTPNRNIAVD ESLMLFKGPL AMKQYLPTKR VRFGLKLYVL CESQSGYVWN ALVHTGPGMN
LKDSADGLKS SRIVLTLVND LLGQGYCVFL DNFNISPMLF RELHQNRTDA VGTARLNRKQ
IPNDLKKRIA KGTTVARFCG ELMALKWCDG KEVTMLSTFH NDTVIEVNNR NGKKTKRPRV
IVDYNENMGA VDSADQMLTS YPSERKRHKV WYKKFFHHLL HITVLNSYIL FKKDNPEHTM
SHINFRLALI ERMLEKHHKP GQQHLRGRPC SDDVTPLRLS GRHFPKSIPA TSGKQNPTGR
CKICCSQYDK DGKKIRKETR YFCAECDVPL CVVPCFEIYH TKKNY
