PGCB_FELCA
ID PGCB_FELCA Reviewed; 417 AA.
AC P41725;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 23-FEB-2022, entry version 114.
DE RecName: Full=Brevican core protein;
DE AltName: Full=Brain-enriched hyaluronan-binding protein;
DE Short=BEHAB;
DE Flags: Precursor; Fragment;
GN Name=BCAN;
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=7512973; DOI=10.1083/jcb.125.2.495;
RA Jaworski D.M., Kelly G.M., Hockfield S.;
RT "BEHAB, a new member of the proteoglycan tandem repeat family of
RT hyaluronan-binding proteins that is restricted to the brain.";
RL J. Cell Biol. 125:495-509(1994).
RN [2]
RP IDENTIFICATION OF PROBABLE FRAMESHIFT.
RX PubMed=7488217; DOI=10.1006/bbrc.1995.2713;
RA Yamada H., Watanabe K., Shimonaka M., Yamasaki M., Yamaguchi Y.;
RT "cDNA cloning and the identification of an aggrecanase-like cleavage site
RT in rat brevican.";
RL Biochem. Biophys. Res. Commun. 216:957-963(1995).
CC -!- FUNCTION: May play a role in the terminally differentiating and the
CC adult nervous system during postnatal development. Could stabilize
CC interactions between hyaluronan (HA) and brain proteoglycans.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Central nervous system.
CC -!- PTM: Contains mostly chondroitin sulfate.
CC -!- SIMILARITY: Belongs to the aggrecan/versican proteoglycan family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA82216.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; Z28367; CAA82216.1; ALT_FRAME; mRNA.
DR PIR; I46268; I46268.
DR STRING; 9685.ENSFCAP00000006092; -.
DR PRIDE; P41725; -.
DR InParanoid; P41725; -.
DR Proteomes; UP000011712; Unplaced.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005540; F:hyaluronic acid binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0001501; P:skeletal system development; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.10.100.10; -; 2.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR000538; Link_dom.
DR Pfam; PF07686; V-set; 1.
DR Pfam; PF00193; Xlink; 2.
DR PRINTS; PR01265; LINKMODULE.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SMART; SM00445; LINK; 2.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF56436; SSF56436; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
DR PROSITE; PS01241; LINK_1; 2.
DR PROSITE; PS50963; LINK_2; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Extracellular matrix; Glycoprotein; Hyaluronic acid;
KW Immunoglobulin domain; Proteoglycan; Reference proteome; Repeat; Secreted;
KW Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..>417
FT /note="Brevican core protein"
FT /id="PRO_0000017510"
FT DOMAIN 23..155
FT /note="Ig-like V-type"
FT DOMAIN 157..252
FT /note="Link 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00323"
FT DOMAIN 257..354
FT /note="Link 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00323"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 337
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 57..137
FT /evidence="ECO:0000250"
FT DISULFID 179..250
FT /evidence="ECO:0000250"
FT DISULFID 203..224
FT /evidence="ECO:0000250"
FT DISULFID 277..352
FT /evidence="ECO:0000250"
FT DISULFID 301..322
FT /evidence="ECO:0000250"
FT NON_TER 417
SQ SEQUENCE 417 AA; 44989 MW; BDFAAADFC8A1E6A9 CRC64;
MAPLFLPLLI ALALAPGPTA SADVLEGDSS EDRAFRVRIS GNAPLQGVLG GALTISCHVH
YLRPPPGRRA VLGSPRVKWT FLSGGREAEV LVARGLRVKV SEAYRFRVAL PAYPASLTDV
SLALSELRPN DSGIYRCEVQ HGIDDSSDAV EVKVKGVVFL YREGSARYAF SFARAQEACA
RIGARIATPE QLYAAYLGGY EQCDAGWLSD QTVRYPIQTP REACYGDMDG FPGVRNYGLV
DPDDLYDIYC YAEDLNGELF LGAPPDNVTL EEATAYCRER GAEIATTGQL YAAWDGGLDR
CSPGWLADGS VRYPIVTPSQ RCGGGLPGVK TLFLFPNQTG FPNKYSRFNV YCFRDSGQPS
TTPEASXPAS DGLEAIVTVT ETLEELHVPR EAVESESRGA IYSVPIVEDG GGARSPP