PGFRL_MACFA
ID PGFRL_MACFA Reviewed; 375 AA.
AC Q2PFX1;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-FEB-2006, sequence version 1.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=Platelet-derived growth factor receptor-like protein;
DE Short=PDGFR-like protein;
DE Flags: Precursor;
GN Name=PDGFRL; ORFNames=QflA-15761;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Frontal cortex;
RA Kobayashi M., Tanuma R., Hirata M., Osada N., Kusuda J., Sugano S.,
RA Hashimoto K.;
RT "Analysis of gene expression in cynomolgus monkey tissues by macaque cDNA
RT oligo-chips.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Forms a complex composed of PDGFRL, TNK2 and GRB2.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AB220466; BAE72999.1; -; mRNA.
DR RefSeq; NP_001271862.1; NM_001284933.1.
DR AlphaFoldDB; Q2PFX1; -.
DR STRING; 9541.XP_005562731.1; -.
DR GeneID; 102145218; -.
DR CTD; 5157; -.
DR eggNOG; KOG0200; Eukaryota.
DR OrthoDB; 825016at2759; -.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR042495; PDGFRL.
DR PANTHER; PTHR15360:SF1; PTHR15360:SF1; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; SSF48726; 3.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..375
FT /note="Platelet-derived growth factor receptor-like
FT protein"
FT /id="PRO_0000233091"
FT DOMAIN 62..159
FT /note="Ig-like C2-type 1"
FT DOMAIN 272..375
FT /note="Ig-like C2-type 2"
FT REGION 22..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 132
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 219
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..143
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 293..357
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 375 AA; 41834 MW; 99C6C88E1B815F0F CRC64;
MKVWLLLGLL LVHEALEDVT GQHLPKNKRP KEPGENRIKP TNKKVKPKIP KIKDRDSADS
TPKTQSIMMQ VLDKGRFQKP AATLSLLAGQ SVELRCKGSR IGWSYPAYLD TFKDSRISVK
QNERYGQLTL VNSTSADTGE FSCWGQLCSG YICRKDETKT GSTYIFFTEK GELFVPSPSY
FDVVYLNPDR QAVVPCRVTV LSAKVTLHRE FPAKEIPANG TDIVYDMKRG FVYLQPHSEH
QGVVYCRAEA GGRSQISVKY QLLYVAVPSG PPSTTILASS NKVKSGDDVS VLCTVLGEPD
VEVEFTWIFP GQKDERPVTI QDTWRLIHRG LGHTTRLSQS VITVEDFETI DAGYYICTAQ
NLQGQTTVAT TVEFS