PGFRL_MOUSE
ID PGFRL_MOUSE Reviewed; 375 AA.
AC Q6PE55; Q3V182; Q9D0Z1;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Platelet-derived growth factor receptor-like protein;
DE Short=PDGFR-like protein;
DE Flags: Precursor;
GN Name=Pdgfrl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Forms a complex composed of PDGFRL, TNK2 and GRB2.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AK004179; BAB23210.1; -; mRNA.
DR EMBL; AK132625; BAE21269.1; -; mRNA.
DR EMBL; BC058275; AAH58275.1; -; mRNA.
DR CCDS; CCDS22259.1; -.
DR RefSeq; NP_081116.3; NM_026840.3.
DR AlphaFoldDB; Q6PE55; -.
DR SMR; Q6PE55; -.
DR STRING; 10090.ENSMUSP00000034004; -.
DR GlyGen; Q6PE55; 1 site.
DR iPTMnet; Q6PE55; -.
DR PhosphoSitePlus; Q6PE55; -.
DR PaxDb; Q6PE55; -.
DR PRIDE; Q6PE55; -.
DR ProteomicsDB; 287920; -.
DR DNASU; 68797; -.
DR GeneID; 68797; -.
DR KEGG; mmu:68797; -.
DR UCSC; uc009lni.2; mouse.
DR CTD; 5157; -.
DR MGI; MGI:1916047; Pdgfrl.
DR eggNOG; KOG0200; Eukaryota.
DR InParanoid; Q6PE55; -.
DR OrthoDB; 825016at2759; -.
DR PhylomeDB; Q6PE55; -.
DR BioGRID-ORCS; 68797; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Pdgfrl; mouse.
DR PRO; PR:Q6PE55; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q6PE55; protein.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR042495; PDGFRL.
DR PANTHER; PTHR15360:SF1; PTHR15360:SF1; 1.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; SSF48726; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..375
FT /note="Platelet-derived growth factor receptor-like
FT protein"
FT /id="PRO_0000233092"
FT DOMAIN 47..159
FT /note="Ig-like C2-type 1"
FT DOMAIN 272..375
FT /note="Ig-like C2-type 2"
FT REGION 20..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 219
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..143
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 293..357
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 20
FT /note="A -> G (in Ref. 1; BAB23210/BAE21269)"
FT /evidence="ECO:0000305"
FT CONFLICT 327
FT /note="I -> V (in Ref. 1; BAB23210)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 375 AA; 41928 MW; D87133C6BF9F7326 CRC64;
MKFWLLLGLL LLHEALEDVA GQHSPKNKRP KEQGENRIKP TNKKAKPKIP KVKDRDSTDS
TAKSQSIMMQ AMGNGRFQRP AATVSLLAGQ TLELRCKGSK VEWSYPAYLD TFKDSRLTVK
QSERYGQLTL VNSTAADTGE FSCWEQLCNG YICRRDEAKT GSTYIFFTEK GELFVPSPSY
FDVVYLNPDR QAVVPCRVTA PSAKVTLHRE FPAKEIPANG TDIVYDMKRG FVYLQPHSDH
QGVVYCKAEA GGKSQISVKY QLLYVEVPSG PPSTTILASS NKVRGGDDIS VLCTVLGEPD
VEVEFRWLFP GQKDERPVTI QDTWRLIHRG LGHTTRISQS VIIVEDFETI DAGYYICTAQ
NLRGQTTVAT TVEFS
