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PGK_CAMJE
ID   PGK_CAMJE               Reviewed;         400 AA.
AC   Q9PMQ5; Q0P8L2;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Phosphoglycerate kinase {ECO:0000255|HAMAP-Rule:MF_00145};
DE            EC=2.7.2.3 {ECO:0000255|HAMAP-Rule:MF_00145};
GN   Name=pgk {ECO:0000255|HAMAP-Rule:MF_00145}; OrderedLocusNames=Cj1402c;
OS   Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC
OS   11168).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=192222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700819 / NCTC 11168;
RX   PubMed=10688204; DOI=10.1038/35001088;
RA   Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA   Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA   Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A.,
RA   Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S.,
RA   Barrell B.G.;
RT   "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT   reveals hypervariable sequences.";
RL   Nature 403:665-668(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl
CC         phosphate + ADP; Xref=Rhea:RHEA:14801, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57604, ChEBI:CHEBI:58272, ChEBI:CHEBI:456216; EC=2.7.2.3;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00145};
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC       glyceraldehyde 3-phosphate: step 2/5. {ECO:0000255|HAMAP-
CC       Rule:MF_00145}.
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00145}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00145}.
CC   -!- SIMILARITY: Belongs to the phosphoglycerate kinase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00145}.
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DR   EMBL; AL111168; CAL35511.1; -; Genomic_DNA.
DR   PIR; B81285; B81285.
DR   RefSeq; WP_010891932.1; NC_002163.1.
DR   RefSeq; YP_002344785.1; NC_002163.1.
DR   PDB; 3Q3V; X-ray; 2.14 A; A/B=1-400.
DR   PDBsum; 3Q3V; -.
DR   AlphaFoldDB; Q9PMQ5; -.
DR   SMR; Q9PMQ5; -.
DR   IntAct; Q9PMQ5; 70.
DR   STRING; 192222.Cj1402c; -.
DR   PaxDb; Q9PMQ5; -.
DR   PRIDE; Q9PMQ5; -.
DR   EnsemblBacteria; CAL35511; CAL35511; Cj1402c.
DR   GeneID; 905691; -.
DR   KEGG; cje:Cj1402c; -.
DR   PATRIC; fig|192222.6.peg.1383; -.
DR   eggNOG; COG0126; Bacteria.
DR   HOGENOM; CLU_025427_0_2_7; -.
DR   OMA; DMIFDIG; -.
DR   UniPathway; UPA00109; UER00185.
DR   Proteomes; UP000000799; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004618; F:phosphoglycerate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.1260; -; 2.
DR   HAMAP; MF_00145; Phosphoglyc_kinase; 1.
DR   InterPro; IPR001576; Phosphoglycerate_kinase.
DR   InterPro; IPR015911; Phosphoglycerate_kinase_CS.
DR   InterPro; IPR015824; Phosphoglycerate_kinase_N.
DR   InterPro; IPR036043; Phosphoglycerate_kinase_sf.
DR   PANTHER; PTHR11406; PTHR11406; 1.
DR   Pfam; PF00162; PGK; 1.
DR   PIRSF; PIRSF000724; Pgk; 1.
DR   PRINTS; PR00477; PHGLYCKINASE.
DR   SUPFAM; SSF53748; SSF53748; 1.
DR   PROSITE; PS00111; PGLYCERATE_KINASE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; ATP-binding; Cytoplasm; Glycolysis; Kinase;
KW   Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN           1..400
FT                   /note="Phosphoglycerate kinase"
FT                   /id="PRO_0000145921"
FT   BINDING         22..24
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00145"
FT   BINDING         38
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00145"
FT   BINDING         61..64
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00145"
FT   BINDING         119
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00145"
FT   BINDING         152
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00145"
FT   BINDING         205
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00145"
FT   BINDING         296
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00145"
FT   BINDING         327
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00145"
FT   BINDING         353..356
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00145"
FT   HELIX           7..9
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   STRAND          16..20
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           37..51
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   STRAND          55..59
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           70..72
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           75..85
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   STRAND          93..97
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           98..106
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   STRAND          112..114
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           118..120
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           124..126
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           129..137
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   STRAND          140..144
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           147..149
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   TURN            155..158
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           159..163
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   STRAND          168..171
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           173..185
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   STRAND          191..197
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           202..212
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   TURN            213..215
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   STRAND          217..221
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           226..232
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           244..246
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           247..259
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   STRAND          263..265
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   STRAND          268..277
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   STRAND          283..286
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           287..289
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   STRAND          295..299
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           301..311
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   STRAND          315..321
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           329..331
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           333..344
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   STRAND          345..353
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           354..362
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           366..368
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   STRAND          369..372
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           376..383
FT                   /evidence="ECO:0007829|PDB:3Q3V"
FT   HELIX           389..392
FT                   /evidence="ECO:0007829|PDB:3Q3V"
SQ   SEQUENCE   400 AA;  43591 MW;  1DAB672AC4432BDF CRC64;
     MSDIISIKDI DLAKKKVFIR CDFNVPQDDF LNITDDRRIR SAIPTIRYCL DNGCSVILAS
     HLGRPKEISS KYSLEPVAKR LARLLDKEIV MAKDVIGEDA KTKAMNLKAG EILLLENLRF
     EKGETKNDEN LAKELASMVQ VYINDAFGVC HRAHSSVEAI TKFFDEKHKG AGFLLQKEID
     FASNLIKHPA RPFVAVVGGS KVSGKLQALT NLLPKVDKLI IGGGMAFTFL KALGYDIGNS
     LLEEELLEEA NKILTKGKNL GVKIYLPVDV VAAPACSQDV PMKFVPAQEI PNGWMGLDIG
     PASVRLFKEV ISDAQTIWWN GPMGVFEIDK FSKGSIKMSH YISEGHATSV VGGGDTADVV
     ARAGDADEMT FISTGGGASL ELIEGKELPG VKALRSKENE
 
 
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