PGK_GLACH
ID PGK_GLACH Reviewed; 376 AA.
AC O00852;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Phosphoglycerate kinase;
DE EC=2.7.2.3;
DE Flags: Fragment;
GN Name=PGK;
OS Glaucoma chattoni.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Glaucomidae; Glaucoma.
OX NCBI_TaxID=5883;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Pearlman R.E.;
RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl
CC phosphate + ADP; Xref=Rhea:RHEA:14801, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57604, ChEBI:CHEBI:58272, ChEBI:CHEBI:456216; EC=2.7.2.3;
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC glyceraldehyde 3-phosphate: step 2/5.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the phosphoglycerate kinase family.
CC {ECO:0000305}.
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DR EMBL; AF001850; AAB58242.1; -; Genomic_DNA.
DR AlphaFoldDB; O00852; -.
DR SMR; O00852; -.
DR UniPathway; UPA00109; UER00185.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004618; F:phosphoglycerate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00318; Phosphoglycerate_kinase; 1.
DR Gene3D; 3.40.50.1260; -; 2.
DR InterPro; IPR001576; Phosphoglycerate_kinase.
DR InterPro; IPR015824; Phosphoglycerate_kinase_N.
DR InterPro; IPR036043; Phosphoglycerate_kinase_sf.
DR PANTHER; PTHR11406; PTHR11406; 1.
DR Pfam; PF00162; PGK; 1.
DR PIRSF; PIRSF000724; Pgk; 1.
DR PRINTS; PR00477; PHGLYCKINASE.
DR SUPFAM; SSF53748; SSF53748; 1.
PE 3: Inferred from homology;
KW ATP-binding; Glycolysis; Kinase; Nucleotide-binding; Transferase.
FT CHAIN <1..>376
FT /note="Phosphoglycerate kinase"
FT /id="PRO_0000145852"
FT BINDING 2..4
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 17
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 41..44
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 100
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 148
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 197
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 290
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 321
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 350..353
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT NON_TER 1
FT NON_TER 376
SQ SEQUENCE 376 AA; 40873 MW; A25D27DC6173DDA9 CRC64;
VDFNVPLKEG VVKDPTRIAG SIPSIKKILE TNPRGLVLMS HLGRPDGQRV EKHSLKPVLP
KLEELLGTKV TFLNDCVGKD VEEAVKSSRN GEIILLENLR FHIEEEGKAV DAAGNKVKAD
PKAVKEFRKS LTNLGDLFFN DAFGTAHRAH SSMVGVDHKI RVAGYLLKKE LEYFSKALES
PTLPFCVVLG GAKVKDKIQL INSMLDNVNE MIIGGGMAFT FLKRLHNLEI GNSLFDEEGY
KIVDELLEKA KKKNVKIHLP VDFLCGDSLE ANANTAIHDL QSGIPKGWIG LDAGPKTIAL
NAEVIARANT IVWNGPQGRF EVDKFRNGSS DLLKKVIERT KTGATSIIGG GDTVNLVQQE
KASNKVSHVS TGGGAS
