PGK_SACS2
ID PGK_SACS2 Reviewed; 408 AA.
AC P50317; Q9UWT3;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Phosphoglycerate kinase;
DE EC=2.7.2.3;
GN Name=pgk; OrderedLocusNames=SSO0527; ORFNames=C22_024;
OS Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS (Sulfolobus solfataricus).
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Saccharolobus.
OX NCBI_TaxID=273057;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8521845; DOI=10.1111/j.1432-1033.1995.800_3.x;
RA Jones C.E., Fleming T.M., Cowan D.A., Littlechild J.A., Piper P.W.;
RT "The phosphoglycerate kinase and glyceraldehyde-3-phosphate dehydrogenase
RT genes from the thermophilic archaeon Sulfolobus solfataricus overlap by 8-
RT bp. Isolation, sequencing of the genes and expression in Escherichia
RT coli.";
RL Eur. J. Biochem. 233:800-808(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX PubMed=10701121; DOI=10.1139/g99-108;
RA Charlebois R.L., Singh R.K., Chan-Weiher C.C.-Y., Allard G., Chow C.,
RA Confalonieri F., Curtis B., Duguet M., Erauso G., Faguy D., Gaasterland T.,
RA Garrett R.A., Gordon P., Jeffries A.C., Kozera C., Kushwaha N., Lafleur E.,
RA Medina N., Peng X., Penny S.L., She Q., St Jean A., van der Oost J.,
RA Young F., Zivanovic Y., Doolittle W.F., Ragan M.A., Sensen C.W.;
RT "Gene content and organization of a 281-kbp contig from the genome of the
RT extremely thermophilic archaeon, Sulfolobus solfataricus P2.";
RL Genome 43:116-136(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX PubMed=11427726; DOI=10.1073/pnas.141222098;
RA She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl
CC phosphate + ADP; Xref=Rhea:RHEA:14801, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57604, ChEBI:CHEBI:58272, ChEBI:CHEBI:456216; EC=2.7.2.3;
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC glyceraldehyde 3-phosphate: step 2/5.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- SIMILARITY: Belongs to the phosphoglycerate kinase family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK40847.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAB57772.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X80178; CAA56459.1; -; Genomic_DNA.
DR EMBL; Y18930; CAB57772.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE006641; AAK40847.1; ALT_INIT; Genomic_DNA.
DR PIR; H90198; H90198.
DR PIR; S63528; S63528.
DR RefSeq; WP_009991049.1; NC_002754.1.
DR AlphaFoldDB; P50317; -.
DR SMR; P50317; -.
DR STRING; 273057.SSO0527; -.
DR PRIDE; P50317; -.
DR EnsemblBacteria; AAK40847; AAK40847; SSO0527.
DR GeneID; 1454814; -.
DR GeneID; 44129551; -.
DR KEGG; sso:SSO0527; -.
DR PATRIC; fig|273057.12.peg.526; -.
DR eggNOG; arCOG00496; Archaea.
DR HOGENOM; CLU_025427_0_2_2; -.
DR InParanoid; P50317; -.
DR OMA; DMIFDIG; -.
DR PhylomeDB; P50317; -.
DR BRENDA; 2.7.2.3; 6163.
DR SABIO-RK; P50317; -.
DR UniPathway; UPA00109; UER00185.
DR Proteomes; UP000001974; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0043531; F:ADP binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR GO; GO:0004618; F:phosphoglycerate kinase activity; IBA:GO_Central.
DR GO; GO:0006094; P:gluconeogenesis; IBA:GO_Central.
DR GO; GO:0006096; P:glycolytic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1260; -; 2.
DR HAMAP; MF_00145; Phosphoglyc_kinase; 1.
DR InterPro; IPR001576; Phosphoglycerate_kinase.
DR InterPro; IPR015911; Phosphoglycerate_kinase_CS.
DR InterPro; IPR015824; Phosphoglycerate_kinase_N.
DR InterPro; IPR036043; Phosphoglycerate_kinase_sf.
DR PANTHER; PTHR11406; PTHR11406; 1.
DR Pfam; PF00162; PGK; 1.
DR PIRSF; PIRSF000724; Pgk; 1.
DR PRINTS; PR00477; PHGLYCKINASE.
DR SUPFAM; SSF53748; SSF53748; 1.
DR PROSITE; PS00111; PGLYCERATE_KINASE; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; Glycolysis; Kinase; Nucleotide-binding;
KW Reference proteome; Transferase.
FT CHAIN 1..408
FT /note="Phosphoglycerate kinase"
FT /id="PRO_0000146071"
FT BINDING 24..26
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 40
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 63..66
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 120
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 160
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 331
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 357..360
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 408 AA; 44396 MW; 9EBF90068315C099 CRC64;
MGDLTIPTMD DIDIQSKKVL LRIDINSPVD ENGKIIDDSR IKAHIGTIKE LINKGNSVVL
ISHQGRPGDK DFTSLEEHAK LISKYLDREV IFVDDVIGPY AREMIKKLEN NGILLLDNIR
LISEELIEAP PQQHVKSFLV KKLAPLFDIY INDAFATAHR SQPSIVGFPL ALPSAAGRVM
EREVSALAKI FNAEDTPKIF TLGGGKVHDT IRIIENLVRK RIADRILTGG LVAELFSVAK
GMNLNPKNME ILEKLGILSL IPRARKLLLS GAPIEIPVDY KVEINGNVIE EPASKVTGII
KDIGSTTAEI YSSFIKDAKV VVLRGPMGVI EDERFKSGSK SVLKASLEGQ GYVIIGGGHM
ISALDEDMKI DSSKVHISTG GGALLLFLSG ERLPALEALS MSVVNSGD
