ID   PGL2_CAEEL              Reviewed;         532 AA.
AC   P34266; P34267; P90737;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=P granule abnormality protein 2;
GN   Name=pgl-2 {ECO:0000312|WormBase:B0523.3};
GN   ORFNames=B0523.3 {ECO:0000312|WormBase:B0523.3};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH PGL-1 AND PGL-3,
RP   SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP   DISRUPTION PHENOTYPE.
RX   PubMed=15238518; DOI=10.1534/genetics.103.023093;
RA   Kawasaki I., Amiri A., Fan Y., Meyer N., Dunkelbarger S., Motohashi T.,
RA   Karashima T., Bossinger O., Strome S.;
RT   "The PGL family proteins associate with germ granules and function
RT   redundantly in Caenorhabditis elegans germline development.";
RL   Genetics 167:645-661(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Transient component of P-granule which is involved in
CC       germline development. {ECO:0000269|PubMed:15238518}.
CC   -!- SUBUNIT: Interacts with pgl-1 and pgl-3; association with either pgl-1
CC       or pgl-3 is not required for P-granule localization.
CC       {ECO:0000269|PubMed:15238518}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic granule
CC       {ECO:0000269|PubMed:15238518}. Note=Localizes to P granules only during
CC       postembryonic development. {ECO:0000269|PubMed:15238518}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in the germline.
CC       {ECO:0000269|PubMed:15238518}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in all embryos during the early cleavage
CC       stages until the 100- and 200-cell stage, after which, expression
CC       diminishes. During larval development, first expressed in L1 larvae,
CC       but it is not highly expressed in the germline. Expression in the
CC       germline increases at later larval stages.
CC       {ECO:0000269|PubMed:15238518}.
CC   -!- DISRUPTION PHENOTYPE: Viable, and not temperature sensitive. Triple
CC       knockout with pgl-1 and pgl-3 results in 58% of progeny arresting as
CC       late embryos and 5% as larvae at 26 degrees Celsius.
CC       {ECO:0000269|PubMed:15238518}.
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DR   EMBL; AB120730; BAC87887.1; -; mRNA.
DR   EMBL; FO080165; CCD61729.1; -; Genomic_DNA.
DR   PIR; F88535; F88535.
DR   RefSeq; NP_498911.1; NM_066510.3.
DR   AlphaFoldDB; P34266; -.
DR   SMR; P34266; -.
DR   BioGRID; 46885; 2.
DR   IntAct; P34266; 1.
DR   STRING; 6239.B0523.3; -.
DR   PaxDb; P34266; -.
DR   PeptideAtlas; P34266; -.
DR   EnsemblMetazoa; B0523.3.1; B0523.3.1; WBGene00003993.
DR   EnsemblMetazoa; B0523.3.2; B0523.3.2; WBGene00003993.
DR   GeneID; 182022; -.
DR   UCSC; B0523.3; c. elegans.
DR   CTD; 182022; -.
DR   WormBase; B0523.3; CE20462; WBGene00003993; pgl-2.
DR   eggNOG; ENOG502QVYU; Eukaryota.
DR   GeneTree; ENSGT00970000196090; -.
DR   HOGENOM; CLU_512137_0_0_1; -.
DR   InParanoid; P34266; -.
DR   OMA; FMEICEL; -.
DR   OrthoDB; 1728675at2759; -.
DR   PhylomeDB; P34266; -.
DR   PRO; PR:P34266; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00003993; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0043186; C:P granule; IDA:WormBase.
DR   GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Developmental protein; Differentiation; Oogenesis; Reference proteome.
FT   CHAIN           1..532
FT                   /note="P granule abnormality protein 2"
FT                   /id="PRO_0000058358"
SQ   SEQUENCE   532 AA;  60597 MW;  4C21453F4698FF04 CRC64;
     MKPCKREIVD FDGIRTHFFP NLALYTCYNE ELIAHHSENA NRFTSYVFGA VEDSPTEQEI
     LEILFPENAN PEAISTGMDA CLALGENFLS HYKSFNARLN RQNHSHDLLD AVQEFDEKKI
     LAISRKSRLR KSADSKILTI LVNILLSENQ EEKFMEICEL CSLDLDFDAF VLIKILQLEN
     EENAEEVQII RENVVDQILE QKPFLAHLLK NGPEKIDEIT KLLSVPIIGS SSNQINQLIT
     KICDSSEISD TAVEEHYHQN FKLMNILVRT MIVDRFDLTI DALEQIPVEI KNRMFPGIRI
     RVLQDTLHFL HQLFKVFLNE SQKFDNLAPQ SFAKAIKNVW VRHAIIGILD SLKFSLNKDV
     FNQLVPLIPG SQVSNDVISG KVENAISCAI WIVKTFGTEG SRDSIEKLPW FDSSVELTEL
     INSIEIAVTS VEVEDQTVNF RKIPQKDWLD GNLQKALKTE PTSEKFGISN SLKIKDENQR
     NQIRGFKDNS KEPNAKVSAR FGSKFQRVDS STKRRLFGGV GVGEPRNCRG FL