ID   PGLB2_XENBO             Reviewed;          21 AA.
AC   C0HK87;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2016, sequence version 1.
DT   25-MAY-2022, entry version 4.
DE   RecName: Full=Peptide PGLa-B2 {ECO:0000303|PubMed:20656059};
OS   Xenopus borealis (Kenyan clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8354 {ECO:0000303|PubMed:20656059};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, MASS SPECTROMETRY, AND
RP   AMIDATION AT LEU-21.
RC   TISSUE=Skin secretion {ECO:0000303|PubMed:20656059};
RX   PubMed=20656059; DOI=10.1016/j.cbpc.2010.07.007;
RA   Mechkarska M., Ahmed E., Coquet L., Leprince J., Jouenne T., Vaudry H.,
RA   King J.D., Conlon J.M.;
RT   "Antimicrobial peptides with therapeutic potential from skin secretions of
RT   the Marsabit clawed frog Xenopus borealis (Pipidae).";
RL   Comp. Biochem. Physiol. 152:467-472(2010).
CC   -!- FUNCTION: Has antimicrobial activity against Gram-negative bacterium
CC       E.coli ATCC 25922 (MIC=25 uM), Gram-positive bacterium S.auerus ATCC
CC       25923 (MIC=50 uM) and against fungus C.albicans ATCC 90028 (MIC=25 uM).
CC       Has some hemolytic activity against human erythrocytes at high
CC       concentration. {ECO:0000269|PubMed:20656059}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20656059}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000305|PubMed:20656059}.
CC   -!- MASS SPECTROMETRY: Mass=1955.2; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:20656059};
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family. Magainin
CC       subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; C0HK87; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Cytolysis; Direct protein sequencing;
KW   Fungicide; Hemolysis; Secreted.
FT   PEPTIDE         1..21
FT                   /note="Peptide PGLa-B2"
FT                   /evidence="ECO:0000269|PubMed:20656059"
FT                   /id="PRO_0000438427"
FT   MOD_RES         21
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:20656059"
SQ   SEQUENCE   21 AA;  1956 MW;  B52B49474B578BF6 CRC64;
     GMASKAGSIV GKIAKIALGA L