ID   PGMG_ASPTE              Reviewed;         560 AA.
AC   A0A1W5SP56;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2017, sequence version 1.
DT   03-AUG-2022, entry version 17.
DE   RecName: Full=MFS-type transporter pgmG {ECO:0000303|PubMed:35351612};
DE   AltName: Full=Pigmented naphthoquinones biosynthesis cluster protein G {ECO:0000303|PubMed:35351612};
GN   Name=pgmG {ECO:0000303|PubMed:28471414};
OS   Aspergillus terreus.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=33178;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION, AND FUNCTION.
RC   STRAIN=MUCL38669;
RX   PubMed=28471414; DOI=10.3390/microorganisms5020022;
RA   Palonen E.K., Raina S., Brandt A., Meriluoto J., Keshavarz T., Soini J.T.;
RT   "Melanisation of Aspergillus terreus-is butyrolactone I involved in the
RT   regulation of both DOPA and DHN types of pigments in submerged culture?";
RL   Microorganisms 5:0-0(2017).
RN   [2]
RP   FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=35351612; DOI=10.1016/j.fgb.2022.103690;
RA   Tang S., Men P., Zhang W., Li H., Li Z., Huang X., Lu X.;
RT   "Identification of a polyketide biosynthesis gene cluster by
RT   transcriptional regulator activation in Aspergillus terreus.";
RL   Fungal Genet. Biol. 160:103690-103690(2022).
CC   -!- FUNCTION: MFS-type transporter; part of the gene cluster that mediates
CC       the biosynthesis of pleosporalin A, ascomycone A, as well as a third
CC       cryptic naphthoquinone derived pigment, all responsible for the
CC       coloration of conidia (PubMed:28471414, PubMed:35351612). Seems not to
CC       be involved in pigment biosynthesis although its expression is
CC       regulated by the cluster-specific transcription factor pgmR
CC       (PubMed:35351612). {ECO:0000269|PubMed:28471414,
CC       ECO:0000269|PubMed:35351612}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Expression is positively regulated by the pgm cluster-
CC       specific transcription factor pgmR. {ECO:0000269|PubMed:35351612}.
CC   -!- DISRUPTION PHENOTYPE: Does not affect the production of the
CC       naphthoquinones derived pigments. {ECO:0000269|PubMed:35351612}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000305}.
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DR   EMBL; KX470751; ARB51368.1; -; mRNA.
DR   VEuPathDB; FungiDB:ATEG_06210; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..560
FT                   /note="MFS-type transporter pgmG"
FT                   /id="PRO_0000456013"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        440..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        515..535
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        300
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        343
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   560 AA;  60319 MW;  59C2B1C7B7A2C527 CRC64;
     MSETVTQTET DQRPATARSL GAEEKEAKSD EQFQQERTIK GFRWFIVIIS ILSSVTLYSL
     DNTIVADIQP QIINTFDELD KLPWLSVAFL VACVATNSIW SKIYSQLNAK WLYLFCVVLF
     EVGSAMCGAA PTINTLIGGR ALAGLGGAGL YVGVMTLLSV NTTKRERPMY IGMTGLTWGV
     GTVLGPIVGG GFAVSKVGWR WSFYINLFFA AVAIPIYLFM LPSFDPRPGV SYKERLAQLD
     YLGTILMIGA CVSGVMAINF GGQIYPWDSG QTISCFVVSG VLFIVFGLQQ WYCIGTTKEN
     RTFPCQFLAR PAFIILFVQT ASVATVFFVP IYFVPLFFQF TRNDSAIDAG VRLLPLVCFI
     VAAMILNGAL MSKFGYYMPW YLVGGCLSLV GSVLMYTIKL GTSTANIYGY MIILGVGGGM
     YAQASFAVAQ GKARPREIPV ATGFISLAQL TGGTIALAIA NSVFLEKASA GIMAVVPDAS
     KETVQSAISG ASSSFFQTLD PDVREAVLAA VTHAISQVYI LPITGAAMSI SLAIFMPREK
     LFVASDTGDR DGVTPLGAMG