PGMI_CALBD
ID PGMI_CALBD Reviewed; 339 AA.
AC Q44407; B9MPI2;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 2.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Bifunctional phosphoglucose/phosphomannose isomerase;
DE AltName: Full=Glucose-6-phosphate isomerase;
DE Short=GPI;
DE EC=5.3.1.9;
DE AltName: Full=Mannose-6-phosphate isomerase;
DE EC=5.3.1.8;
DE AltName: Full=Phosphoglucose isomerase;
DE Short=PGI;
DE AltName: Full=Phosphomannose isomerase;
DE Short=PMI;
GN OrderedLocusNames=Athe_0619;
OS Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320)
OS (Anaerocellum thermophilum).
OC Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacterales Family III. Incertae Sedis; Caldicellulosiruptor.
OX NCBI_TaxID=521460;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Zverlov V.V., Bronnenmeier K., Velikodvorskaya G.A.;
RL Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1888 / DSM 6725 / Z-1320;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA Goodwin L., Pitluck S., Sims D., Meincke L., Brettin T., Detter J.C.,
RA Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA Kataeva I., Adams M.W.W.;
RT "Complete sequence of chromosome of Anaerocellum thermophilum DSM 6725.";
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the isomerization of both glucose 6-phosphate and
CC epimeric mannose 6-phosphate at a similar catalytic efficiency.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC EC=5.3.1.9;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-mannose 6-phosphate = D-fructose 6-phosphate;
CC Xref=Rhea:RHEA:12356, ChEBI:CHEBI:58735, ChEBI:CHEBI:61527;
CC EC=5.3.1.8;
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PGI/PMI family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ACM59743.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAA93628.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; Z69782; CAA93628.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP001393; ACM59743.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_015907196.1; NC_012034.1.
DR AlphaFoldDB; Q44407; -.
DR SMR; Q44407; -.
DR STRING; 521460.Athe_0619; -.
DR EnsemblBacteria; ACM59743; ACM59743; Athe_0619.
DR GeneID; 31771974; -.
DR KEGG; ate:Athe_0619; -.
DR eggNOG; COG2222; Bacteria.
DR HOGENOM; CLU_059687_0_0_9; -.
DR OrthoDB; 1179564at2; -.
DR Proteomes; UP000007723; Chromosome.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd05017; SIS_PGI_PMI_1; 1.
DR CDD; cd05637; SIS_PGI_PMI_2; 1.
DR InterPro; IPR019490; Glu6P/Mann6P_isomerase_C.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR InterPro; IPR035484; SIS_PGI/PMI_1.
DR Pfam; PF10432; bact-PGI_C; 1.
DR Pfam; PF01380; SIS; 1.
DR SUPFAM; SSF53697; SSF53697; 1.
DR PROSITE; PS51464; SIS; 1.
PE 3: Inferred from homology;
KW Isomerase; Multifunctional enzyme.
FT CHAIN 1..339
FT /note="Bifunctional phosphoglucose/phosphomannose
FT isomerase"
FT /id="PRO_0000227792"
FT DOMAIN 22..164
FT /note="SIS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00797"
FT ACT_SITE 221
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT ACT_SITE 237
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT ACT_SITE 331
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
SQ SEQUENCE 339 AA; 37787 MW; 7C5EE355D649B091 CRC64;
MFESVYNLPE QIQKAYEIGK NISVNVKAED IDKVVITGLG GSAIGGNLLR VFVLDKCKIP
VIVNRDYVLP AYVDSKTLVI ASSYSGNTEE TLSAYQDAKA KGAKIIAITT GGKLKEFAEK
DGFDVITIPS GLQPRAALGY SFIPLLMLFV KLGLIEPVDD QIEETVKVLS DLRERYKPEV
PEEKNLAKRL TLKLWNKLPI IYGISGTTEV IAERWKGQIC ENSKSPAYFN VFSELNHNEI
VGTESPKHIL GLFEIVMLHD TEDHKRNAIR MDITKDLIKG VVSGVNDIYS IGNSRLARMF
SLIYLGDYVS LYLATLYQND PTPVKKIDIL KNKLAEIKD
