PGML2_ARATH
ID PGML2_ARATH Reviewed; 343 AA.
AC F4IBB2; F4IBB1; Q0WU57; Q9LQB8; Q9SLV2;
DT 29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Phosphoglycerate mutase-like protein 2 {ECO:0000305};
DE Flags: Precursor;
GN OrderedLocusNames=At1g58280 {ECO:0000312|Araport:AT1G58280};
GN ORFNames=F19C14.10 {ECO:0000312|EMBL:AAF82259.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-343 (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 20-343 (ISOFORM 2).
RX PubMed=10548732; DOI=10.1016/s0378-1119(99)00403-5;
RA Kato A., Suzuki M., Kuwahara A., Ooe H., Higano-Inaba K., Komeda Y.;
RT "Isolation and analysis of cDNA within a 300 kb Arabidopsis thaliana
RT genomic region located around the 100 map unit of chromosome 1.";
RL Gene 239:309-316(1999).
CC -!- FUNCTION: May play a role in carbohydrates metabolism.
CC {ECO:0000250|UniProtKB:Q9MAA2}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F4IBB2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F4IBB2-2; Sequence=VSP_056878;
CC -!- SIMILARITY: Belongs to the phosphoglycerate mutase family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF82259.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC008051; AAF82259.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002684; AEE33528.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33529.1; -; Genomic_DNA.
DR EMBL; AK227327; BAE99341.1; -; mRNA.
DR EMBL; AB028195; BAA87937.1; -; mRNA.
DR PIR; D96616; D96616.
DR PIR; T52444; T52444.
DR RefSeq; NP_176124.2; NM_104608.4. [F4IBB2-2]
DR RefSeq; NP_849826.2; NM_179495.3. [F4IBB2-1]
DR AlphaFoldDB; F4IBB2; -.
DR STRING; 3702.AT1G58280.2; -.
DR iPTMnet; F4IBB2; -.
DR PaxDb; F4IBB2; -.
DR PRIDE; F4IBB2; -.
DR ProteomicsDB; 235074; -. [F4IBB2-1]
DR DNASU; 842197; -.
DR EnsemblPlants; AT1G58280.1; AT1G58280.1; AT1G58280. [F4IBB2-2]
DR EnsemblPlants; AT1G58280.2; AT1G58280.2; AT1G58280. [F4IBB2-1]
DR GeneID; 842197; -.
DR Gramene; AT1G58280.1; AT1G58280.1; AT1G58280. [F4IBB2-2]
DR Gramene; AT1G58280.2; AT1G58280.2; AT1G58280. [F4IBB2-1]
DR KEGG; ath:AT1G58280; -.
DR Araport; AT1G58280; -.
DR TAIR; locus:2016640; AT1G58280.
DR eggNOG; KOG4754; Eukaryota.
DR InParanoid; F4IBB2; -.
DR OrthoDB; 1063916at2759; -.
DR PhylomeDB; F4IBB2; -.
DR PRO; PR:F4IBB2; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4IBB2; baseline and differential.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR CDD; cd07067; HP_PGM_like; 1.
DR Gene3D; 3.40.50.1240; -; 1.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR Pfam; PF00300; His_Phos_1; 1.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF53254; SSF53254; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chloroplast; Plastid; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..35
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 36..343
FT /note="Phosphoglycerate mutase-like protein 2"
FT /evidence="ECO:0000255"
FT /id="PRO_0000430633"
FT REGION 322..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 65
FT /note="Tele-phosphohistidine intermediate"
FT /evidence="ECO:0000250|UniProtKB:P62707"
FT ACT_SITE 177
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000250|UniProtKB:P62707"
FT SITE 273
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000250|UniProtKB:P62707"
FT VAR_SEQ 180..204
FT /note="Missing (in isoform 2)"
FT /id="VSP_056878"
FT CONFLICT 33
FT /note="R -> H (in Ref. 3; BAE99341)"
SQ SEQUENCE 343 AA; 38605 MW; FAFADCA87B3D988B CRC64;
MIHQSMTSNL SFYISSVSHL SSPLPSLSRL SLRCCSSLPA HDMETKPSQG LYPLHRCKTI
HLVRHAQGIH NVEGEKNHKA YLSEDLFDAH LTPLGWQQVD NLHKHVNASG ISNRIELVVV
SPLLRTLQTA VGTFGGEGYK DGVNTPLLMT AGAGNSDRPA ISRLNRPPFI AVESCREHLV
CLLFYLLHDW HFLEMKTFAM FLVQGVHPCD RRSNITKYRE LFPAIDFSLI ETDEDVLWKP
DIREEDKDIA TRGVKFFNWL STRKEKEIAV VTHSGFLYQT LNSFGNDCDP SVKNEISKKF
VNCELRSFVL VDKCMSSSDP PMTNYPGTIL TGEDASSDIA DQK
