ID   PGP2_SACS2              Reviewed;         233 AA.
AC   P95931;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Phosphoglycolate phosphatase 2;
DE            Short=PGP 2;
DE            Short=PGPase 2;
DE            EC=3.1.3.18;
GN   OrderedLocusNames=SSO2157; ORFNames=C01033;
OS   Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS   (Sulfolobus solfataricus).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Saccharolobus.
OX   NCBI_TaxID=273057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=11427726; DOI=10.1073/pnas.141222098;
RA   She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA   Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA   Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA   Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA   Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA   Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT   "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
CC   -!- FUNCTION: Catalyzes the dephosphorylation of 2-phosphoglycolate.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-phosphoglycolate + H2O = glycolate + phosphate;
CC         Xref=Rhea:RHEA:14369, ChEBI:CHEBI:15377, ChEBI:CHEBI:29805,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58033; EC=3.1.3.18;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the archaeal SPP-like hydrolase family.
CC       {ECO:0000305}.
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DR   EMBL; Y08256; CAA69435.1; -; Genomic_DNA.
DR   EMBL; AE006641; AAK42333.1; -; Genomic_DNA.
DR   PIR; S74064; S74064.
DR   RefSeq; WP_009992158.1; NC_002754.1.
DR   AlphaFoldDB; P95931; -.
DR   SMR; P95931; -.
DR   STRING; 273057.SSO2157; -.
DR   DNASU; 1453660; -.
DR   EnsemblBacteria; AAK42333; AAK42333; SSO2157.
DR   GeneID; 44130868; -.
DR   GeneID; 58783396; -.
DR   KEGG; sso:SSO2157; -.
DR   PATRIC; fig|273057.12.peg.2250; -.
DR   eggNOG; arCOG01213; Archaea.
DR   HOGENOM; CLU_1237940_0_0_2; -.
DR   InParanoid; P95931; -.
DR   OMA; MWIVASD; -.
DR   PhylomeDB; P95931; -.
DR   Proteomes; UP000001974; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0000287; F:magnesium ion binding; IBA:GO_Central.
DR   GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR   GO; GO:0008967; F:phosphoglycolate phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   HAMAP; MF_01419; GPH_hydrolase_arch; 1.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006379; HAD-SF_hydro_IIB.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR006382; PGPase.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR01484; HAD-SF-IIB; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Magnesium; Metal-binding;
KW   Reference proteome.
FT   CHAIN           1..233
FT                   /note="Phosphoglycolate phosphatase 2"
FT                   /id="PRO_0000146729"
FT   ACT_SITE        13
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   BINDING         13
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         15
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         152
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         174
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         178
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   233 AA;  26215 MW;  5E3AE64515CAAD90 CRC64;
     MDIGSNEILV ASDYDRTLAS EENNFVISPI VSQKVNEFSK KYKFVVVTGR EKKFIDKLAV
     GLKPTAWILE NGSLILFNDR EFVLCEKSWF ERDRKKIIEI LDNLKVRYSI GRIILYVDGY
     GSKLDMLSEI EKYGRIEVNR NDAMILPKGV DKGVGVLKFK ELTGFKGKII ALGDSENDYA
     LFRVADIKVA VANAIPQIKE IADIVTENPN GLGVVEILDK ILSGNFGKEV DIY