PGPIL_HUMAN
ID PGPIL_HUMAN Reviewed; 196 AA.
AC A6NFU8; H0YF86;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 4.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Pyroglutamyl-peptidase 1-like protein;
DE EC=3.4.19.-;
GN Name=PGPEP1L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT VAL-142.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6NFU8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6NFU8-2; Sequence=VSP_053799;
CC -!- SIMILARITY: Belongs to the peptidase C15 family. {ECO:0000305}.
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DR EMBL; AC069029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC104743; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC036108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS53977.1; -. [A6NFU8-1]
DR CCDS; CCDS58400.1; -. [A6NFU8-2]
DR RefSeq; NP_001096082.2; NM_001102612.2. [A6NFU8-1]
DR RefSeq; NP_001161374.1; NM_001167902.1. [A6NFU8-2]
DR RefSeq; XP_016877422.1; XM_017021933.1. [A6NFU8-2]
DR AlphaFoldDB; A6NFU8; -.
DR SMR; A6NFU8; -.
DR STRING; 9606.ENSP00000368199; -.
DR BioMuta; PGPEP1L; -.
DR PaxDb; A6NFU8; -.
DR PRIDE; A6NFU8; -.
DR ProteomicsDB; 1078; -. [A6NFU8-1]
DR ProteomicsDB; 37991; -.
DR Antibodypedia; 51235; 16 antibodies from 9 providers.
DR DNASU; 145814; -.
DR Ensembl; ENST00000378919.6; ENSP00000368199.6; ENSG00000183571.11. [A6NFU8-1]
DR Ensembl; ENST00000535714.2; ENSP00000437560.1; ENSG00000183571.11. [A6NFU8-2]
DR GeneID; 145814; -.
DR KEGG; hsa:145814; -.
DR MANE-Select; ENST00000535714.2; ENSP00000437560.1; NM_001167902.2; NP_001161374.1. [A6NFU8-2]
DR UCSC; uc002bum.4; human. [A6NFU8-1]
DR CTD; 145814; -.
DR DisGeNET; 145814; -.
DR GeneCards; PGPEP1L; -.
DR HGNC; HGNC:27080; PGPEP1L.
DR HPA; ENSG00000183571; Tissue enriched (skeletal).
DR neXtProt; NX_A6NFU8; -.
DR OpenTargets; ENSG00000183571; -.
DR PharmGKB; PA165479208; -.
DR VEuPathDB; HostDB:ENSG00000183571; -.
DR eggNOG; KOG4755; Eukaryota.
DR GeneTree; ENSGT00390000015368; -.
DR HOGENOM; CLU_043960_3_0_1; -.
DR InParanoid; A6NFU8; -.
DR OMA; VVYQKAK; -.
DR OrthoDB; 1248044at2759; -.
DR PhylomeDB; A6NFU8; -.
DR TreeFam; TF313278; -.
DR PathwayCommons; A6NFU8; -.
DR BioGRID-ORCS; 145814; 10 hits in 1062 CRISPR screens.
DR ChiTaRS; PGPEP1L; human.
DR GenomeRNAi; 145814; -.
DR Pharos; A6NFU8; Tdark.
DR PRO; PR:A6NFU8; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; A6NFU8; protein.
DR Bgee; ENSG00000183571; Expressed in skeletal muscle tissue and 85 other tissues.
DR ExpressionAtlas; A6NFU8; baseline and differential.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.630.20; -; 1.
DR InterPro; IPR016125; Peptidase_C15-like.
DR InterPro; IPR036440; Peptidase_C15-like_sf.
DR PANTHER; PTHR23402; PTHR23402; 1.
DR Pfam; PF01470; Peptidase_C15; 1.
DR SUPFAM; SSF53182; SSF53182; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Hydrolase; Protease; Reference proteome;
KW Thiol protease.
FT CHAIN 1..196
FT /note="Pyroglutamyl-peptidase 1-like protein"
FT /id="PRO_0000334694"
FT ACT_SITE 65
FT /evidence="ECO:0000250"
FT ACT_SITE 127
FT /evidence="ECO:0000250"
FT ACT_SITE 146
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..54
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_053799"
FT VARIANT 142
FT /note="A -> V (in dbSNP:rs2715423)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_043463"
FT VARIANT 169
FT /note="E -> Q (in dbSNP:rs1521484)"
FT /id="VAR_043464"
FT CONFLICT 3
FT /note="P -> L (in Ref. 2; BC104743)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 196 AA; 21631 MW; 2BA3DD23F8D2ACE3 CRC64;
MKPRTLVELS KLGLGNETVV QLRTLELPVD YREAKRRVTG IWEDHQPQLV VHVGMDTAAK
AIILEQSGKN QGYRDADIRS FWPEGGVCLP GSPDVLESGV CMKAVCKRVA VEGVDVIFSR
DAGRYVCDYT YYLSLHHGKG CAALIHVPPL SRGLPASLLG RALRVIIQEM LEEVGKPKHR
AQFEENSTMV LPAKGN
