ID   PGQ_XENLA               Reviewed;          24 AA.
AC   P39080;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Antimicrobial peptide PGQ;
DE   AltName: Full=Preproprotein pGQ;
GN   Name=pgq;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Stomach;
RX   PubMed=1717472; DOI=10.1016/s0021-9258(18)55069-9;
RA   Moore K.S., Bevins C.L., Brasseur M.M., Tomassini N., Turner K., Eck H.,
RA   Zasloff M.;
RT   "Antimicrobial peptides in the stomach of Xenopus laevis.";
RL   J. Biol. Chem. 266:19851-19857(1991).
CC   -!- FUNCTION: Antimicrobial peptide.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Is synthesized in the stomach and stored in a novel
CC       granular multinucleated cell in the gastric mucosa. It is stored as
CC       active, processed peptides in large granules within the granular gland
CC       secretions of the skin.
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family. Magainin
CC       subfamily. {ECO:0000305}.
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DR   PIR; A41037; A41037.
DR   AlphaFoldDB; P39080; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Reference proteome; Secreted.
FT   PEPTIDE         1..24
FT                   /note="Antimicrobial peptide PGQ"
FT                   /id="PRO_0000043899"
SQ   SEQUENCE   24 AA;  2457 MW;  7E6A87CB7CF22B9C CRC64;
     GVLSNVIGYL KKLGTGALNA VLKQ