PGRP4_MOUSE
ID PGRP4_MOUSE Reviewed; 374 AA.
AC Q0VB07; Q6R1Z1;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Peptidoglycan recognition protein 4;
DE AltName: Full=Peptidoglycan recognition protein I-beta;
DE Short=PGLYRPIbeta;
DE Short=PGRP-I-beta;
DE AltName: Full=Peptidoglycan recognition protein intermediate beta;
DE Flags: Precursor;
GN Name=Pglyrp4; Synonyms=Pgrpib;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=15177568; DOI=10.1016/j.ygeno.2004.01.003;
RA Mathur P., Murray B., Crowell T., Gardner H., Allaire N., Hsu Y.-M.,
RA Thill G., Carulli J.P.;
RT "Murine peptidoglycan recognition proteins PglyrpIalpha and PglyrpIbeta are
RT encoded in the epidermal differentiation complex and are expressed in
RT epidermal and hematopoietic tissues.";
RL Genomics 83:1151-1163(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Pattern receptor that binds to murein peptidoglycans (PGN) of
CC Gram-positive bacteria. Has bactericidal activity towards Gram-positive
CC bacteria. May kill Gram-positive bacteria by interfering with
CC peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and
CC has bacteriostatic activity towards Gram-negative bacteria. Plays a
CC role in innate immunity (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Heterodimer with PGLYRP3;
CC disulfide-linked (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:15177568}.
CC -!- SIMILARITY: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
CC {ECO:0000305}.
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DR EMBL; AY518699; AAS49173.1; -; mRNA.
DR EMBL; BC120840; AAI20841.1; -; mRNA.
DR CCDS; CCDS17544.1; -.
DR RefSeq; NP_997146.2; NM_207263.2.
DR AlphaFoldDB; Q0VB07; -.
DR SMR; Q0VB07; -.
DR STRING; 10090.ENSMUSP00000040755; -.
DR GlyGen; Q0VB07; 3 sites.
DR iPTMnet; Q0VB07; -.
DR PhosphoSitePlus; Q0VB07; -.
DR jPOST; Q0VB07; -.
DR PaxDb; Q0VB07; -.
DR PRIDE; Q0VB07; -.
DR ProteomicsDB; 288188; -.
DR Antibodypedia; 34122; 181 antibodies from 26 providers.
DR DNASU; 384997; -.
DR Ensembl; ENSMUST00000047745; ENSMUSP00000040755; ENSMUSG00000042250.
DR GeneID; 384997; -.
DR KEGG; mmu:384997; -.
DR UCSC; uc008qdg.2; mouse.
DR CTD; 57115; -.
DR MGI; MGI:2686324; Pglyrp4.
DR VEuPathDB; HostDB:ENSMUSG00000042250; -.
DR eggNOG; ENOG502S2KY; Eukaryota.
DR GeneTree; ENSGT00940000162349; -.
DR InParanoid; Q0VB07; -.
DR OMA; AREAHCP; -.
DR TreeFam; TF323898; -.
DR Reactome; R-MMU-6803157; Antimicrobial peptides.
DR BioGRID-ORCS; 384997; 4 hits in 73 CRISPR screens.
DR PRO; PR:Q0VB07; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q0VB07; protein.
DR Bgee; ENSMUSG00000042250; Expressed in esophagus and 10 other tissues.
DR ExpressionAtlas; Q0VB07; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; IEA:InterPro.
DR GO; GO:0042834; F:peptidoglycan binding; ISS:UniProtKB.
DR GO; GO:0016019; F:peptidoglycan immune receptor activity; ISO:MGI.
DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI.
DR GO; GO:0051701; P:biological process involved in interaction with host; IMP:MGI.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:MGI.
DR GO; GO:0016045; P:detection of bacterium; ISO:MGI.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; ISO:MGI.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IMP:MGI.
DR GO; GO:0032827; P:negative regulation of natural killer cell differentiation involved in immune response; IMP:MGI.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR CDD; cd06583; PGRP; 2.
DR Gene3D; 3.40.80.10; -; 2.
DR InterPro; IPR036505; Amidase/PGRP_sf.
DR InterPro; IPR002502; Amidase_domain.
DR InterPro; IPR015510; PGRP.
DR InterPro; IPR006619; PGRP_domain_met/bac.
DR PANTHER; PTHR11022; PTHR11022; 1.
DR Pfam; PF01510; Amidase_2; 2.
DR SMART; SM00644; Ami_2; 2.
DR SMART; SM00701; PGRP; 2.
DR SUPFAM; SSF55846; SSF55846; 2.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Disulfide bond; Glycoprotein; Immunity;
KW Innate immunity; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..374
FT /note="Peptidoglycan recognition protein 4"
FT /id="PRO_0000295275"
FT DOMAIN 76..212
FT /note="N-acetylmuramoyl-L-alanine amidase 1"
FT /evidence="ECO:0000255"
FT DOMAIN 233..359
FT /note="N-acetylmuramoyl-L-alanine amidase 2"
FT /evidence="ECO:0000255"
FT REGION 294..303
FT /note="Interaction with murein"
FT /evidence="ECO:0000250"
FT REGION 354..355
FT /note="Interaction with murein"
FT /evidence="ECO:0000250"
FT BINDING 275
FT /ligand="peptidoglycan"
FT /ligand_id="ChEBI:CHEBI:8005"
FT /evidence="ECO:0000250"
FT CARBOHYD 39
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 93
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 146
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 211..333
FT /evidence="ECO:0000250"
FT DISULFID 227..271
FT /evidence="ECO:0000250"
FT DISULFID 247..253
FT /evidence="ECO:0000250"
FT CONFLICT 334
FT /note="A -> T (in Ref. 1; AAS49173)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 374 AA; 41190 MW; A677F7E1BD621532 CRC64;
MLSWLLVFSI LVLLAQGVSS WENPQTDQVS EGLQQLFGNI SQLFEKGILG RDDVFTMVSR
EEWGAEAIGC SSKLSRPVDV LVIHHIPGLE CHNKTVCSQK LRELQAYHIH NSWCDVAYNF
LVGDDGRVYE GVGWNVQGSH DQGYKNISLG VAFFGTQEGH SPSPVALSAM KGLISYAVKK
GHLSSKYIQP LLAKSEDCLV PPQKGKQKKA CPHIVPRSVW GARDSHCSRM TLPAKYAIIL
HTAGRTCSQP DECRLLVRDL QSFFMNRLNA CDIGYNFLVG QDGGVYEGVG WNNQGSKTDS
YNDISLSITF MGTFTGSPPN AAALEAAQDL IRCAVVKGYL TPNYLLMGHS DVSNTLSPGQ
ALYNIIKTWP HFKH
