ID   PGRP_BOMMO              Reviewed;         196 AA.
AC   Q9XTN0; Q9TWD4;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Peptidoglycan recognition protein;
DE   Flags: Precursor;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], PROTEIN SEQUENCE OF 24-72;
RP   99-118; 147-159 AND 183-196, TISSUE SPECIFICITY, AND INDUCTION.
RC   STRAIN=Kinshu X Showa; TISSUE=Fat body;
RX   PubMed=10207004; DOI=10.1074/jbc.274.17.11854;
RA   Ochiai M., Ashida M.;
RT   "A pattern recognition protein for peptidoglycan. Cloning the cDNA and the
RT   gene of the silkworm, Bombyx mori.";
RL   J. Biol. Chem. 274:11854-11858(1999).
RN   [2]
RP   PROTEIN SEQUENCE OF 24-43, FUNCTION, AND SUBUNIT.
RC   TISSUE=Hemolymph;
RX   PubMed=8662762; DOI=10.1074/jbc.271.23.13854;
RA   Yoshida H., Kinoshita K., Ashida M.;
RT   "Purification of a peptidoglycan recognition protein from hemolymph of the
RT   silkworm, Bombyx mori.";
RL   J. Biol. Chem. 271:13854-13860(1996).
CC   -!- FUNCTION: Binds specifically to peptidoglycan and triggers the
CC       propenoloxidase cascade which is an important insect defense mechanism.
CC       {ECO:0000269|PubMed:8662762}.
CC   -!- SUBUNIT: Monomer. {ECO:0000305|PubMed:8662762}.
CC   -!- TISSUE SPECIFICITY: Constitutively expressed in fat body, epithelial
CC       cells and hemocytes. Not detected in Malpighian tubules, silk gland or
CC       midgut. {ECO:0000269|PubMed:10207004}.
CC   -!- INDUCTION: By bacterial challenge. {ECO:0000269|PubMed:10207004}.
CC   -!- SIMILARITY: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
CC       {ECO:0000305}.
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DR   EMBL; AB016605; BAA77210.1; -; Genomic_DNA.
DR   EMBL; AB016249; BAA77209.1; -; mRNA.
DR   RefSeq; NP_001036836.1; NM_001043371.1.
DR   AlphaFoldDB; Q9XTN0; -.
DR   SMR; Q9XTN0; -.
DR   STRING; 7091.BGIBMGA008038-TA; -.
DR   GeneID; 692372; -.
DR   KEGG; bmor:692372; -.
DR   CTD; 692372; -.
DR   eggNOG; ENOG502S2KY; Eukaryota.
DR   HOGENOM; CLU_037559_3_2_1; -.
DR   OrthoDB; 1110472at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; IEA:InterPro.
DR   GO; GO:0042834; F:peptidoglycan binding; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR   CDD; cd06583; PGRP; 1.
DR   Gene3D; 3.40.80.10; -; 1.
DR   InterPro; IPR036505; Amidase/PGRP_sf.
DR   InterPro; IPR002502; Amidase_domain.
DR   InterPro; IPR017331; Peptidoglycan_recognition.
DR   InterPro; IPR015510; PGRP.
DR   InterPro; IPR006619; PGRP_domain_met/bac.
DR   PANTHER; PTHR11022; PTHR11022; 1.
DR   Pfam; PF01510; Amidase_2; 1.
DR   PIRSF; PIRSF037945; PGRPs; 1.
DR   SMART; SM00644; Ami_2; 1.
DR   SMART; SM00701; PGRP; 1.
DR   SUPFAM; SSF55846; SSF55846; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Immunity; Innate immunity;
KW   Reference proteome; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:10207004,
FT                   ECO:0000269|PubMed:8662762"
FT   CHAIN           24..196
FT                   /note="Peptidoglycan recognition protein"
FT                   /id="PRO_0000023904"
FT   DOMAIN          46..173
FT                   /note="N-acetylmuramoyl-L-alanine amidase"
FT                   /evidence="ECO:0000255"
FT   DISULFID        25..147
FT                   /evidence="ECO:0000255"
FT   DISULFID        61..67
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   196 AA;  21627 MW;  225AD76EC24DA900 CRC64;
     MARLHSAVVL ALALSSLLTE IAADCDVVSK KQWDGLIPVH VSYLARPVSL VIVQHTVTPF
     CRTDAGCEEL VRNIQTNHME ALQYWDIGPS FLVGGNGKVY EGSGWLHVGA HTYGYNSRSI
     GVAFIGNFNT DEPSGAMLEA LRSLLRCGVE RGHLAGDYRA VAHRQLIASE SPGRKLYNQI
     RRWPEWLENV DSIKNA