PGRR_ECOLI
ID PGRR_ECOLI Reviewed; 299 AA.
AC P77333; P76841;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=HTH-type transcriptional regulator PgrR;
DE AltName: Full=Regulator of PG recycling;
GN Name=pgrR; Synonyms=ycjZ; OrderedLocusNames=b1328, JW1321;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA Wada C., Yamamoto Y., Horiuchi T.;
RT "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 28.0-40.1 min region on the linkage map.";
RL DNA Res. 3:363-377(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP FUNCTION, DNA-BINDING, AND GENE NAME.
RX PubMed=23301696; DOI=10.1111/gtc.12026;
RA Shimada T., Yamazaki K., Ishihama A.;
RT "Novel regulator PgrR for switch control of peptidoglycan recycling in
RT Escherichia coli.";
RL Genes Cells 18:123-134(2013).
CC -!- FUNCTION: Regulates the expression of genes involved in peptidoglycan
CC (PG) degradation. Could play a role in switch control between recycling
CC and degradation of PG peptides. Negatively regulates the expression of
CC the ycjY-ymjD-ymjC-mpaA operon by binding to the PgrR-box. In addition,
CC other genes are predicted to be under the control of PgrR, including
CC genes related to membrane formation and function.
CC {ECO:0000269|PubMed:23301696}.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
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DR EMBL; U00096; AAC74410.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA14921.1; -; Genomic_DNA.
DR PIR; C64882; C64882.
DR RefSeq; NP_415844.1; NC_000913.3.
DR RefSeq; WP_000817708.1; NZ_SSZK01000012.1.
DR AlphaFoldDB; P77333; -.
DR SMR; P77333; -.
DR BioGRID; 4260154; 13.
DR DIP; DIP-11617N; -.
DR IntAct; P77333; 7.
DR STRING; 511145.b1328; -.
DR PaxDb; P77333; -.
DR PRIDE; P77333; -.
DR EnsemblBacteria; AAC74410; AAC74410; b1328.
DR EnsemblBacteria; BAA14921; BAA14921; BAA14921.
DR GeneID; 945930; -.
DR KEGG; ecj:JW1321; -.
DR KEGG; eco:b1328; -.
DR PATRIC; fig|511145.12.peg.1386; -.
DR EchoBASE; EB3682; -.
DR eggNOG; COG0583; Bacteria.
DR HOGENOM; CLU_039613_16_1_6; -.
DR InParanoid; P77333; -.
DR OMA; TCIYALR; -.
DR PhylomeDB; P77333; -.
DR BioCyc; EcoCyc:G6664-MON; -.
DR PRO; PR:P77333; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003677; F:DNA binding; IDA:EcoCyc.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:EcoCyc.
DR GO; GO:0071978; P:bacterial-type flagellum-dependent swarming motility; IMP:EcoCyc.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:EcoCyc.
DR GO; GO:0006351; P:transcription, DNA-templated; IDA:EcoCyc.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..299
FT /note="HTH-type transcriptional regulator PgrR"
FT /id="PRO_0000105782"
FT DOMAIN 4..61
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT DNA_BIND 21..40
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ SEQUENCE 299 AA; 33482 MW; 05FB892DD7D19413 CRC64;
MKREEIADLM AFVVVAEERS FTRAAARLSM AQSALSQIVR RIEERLGLRL LTRTTRSVVP
TEAGEHLLSV LGPMLHDIDS AMASLSDLQN RPSGTIRITT VEHAAKTILL PAMRTFLKSH
PEIDIQLTID YGLTDVVSER FDAGVRLGGE MDKDMIAIRI GPDIPMAIVG SPDYFSRRSV
PTSVSQLIDH QAINLYLPTS GTANRWRLIR GGREVRVRME GQLLLNTIDL IIDAAIDGHG
LAYLPYDQVE RAIKEKKLIR VLDKFTPDLP GYHLYYPHRR HAGSAFSLFI DRLKYKGAV
