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PGR_ARATH
ID   PGR_ARATH               Reviewed;         288 AA.
AC   Q0WP96; Q8LF53;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Protein PGR {ECO:0000303|Ref.6};
DE            Short=AtPGR {ECO:0000303|Ref.6};
DE   AltName: Full=Plasma membrane glucose-responsive regulator {ECO:0000303|Ref.6};
DE   AltName: Full=Transmembrane protein 19-like protein {ECO:0000305};
DE   AltName: Full=VTE6-related protein {ECO:0000303|PubMed:26452599};
DE            Short=VTE6R {ECO:0000303|PubMed:26452599};
GN   Name=PGR {ECO:0000303|Ref.6};
GN   OrderedLocusNames=At5g19930 {ECO:0000312|Araport:AT5G19930};
GN   ORFNames=F28I16.80 {ECO:0000305};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|EMBL:BAF01053.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY.
RX   PubMed=26452599; DOI=10.1105/tpc.15.00395;
RA   Vom Dorp K., Hoelzl G., Plohmann C., Eisenhut M., Abraham M., Weber A.P.,
RA   Hanson A.D., Doermann P.;
RT   "Remobilization of phytol from chlorophyll degradation is essential for
RT   tocopherol synthesis and growth of Arabidopsis.";
RL   Plant Cell 27:2846-2859(2015).
RN   [6]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION BY
RP   GLUCOSE.
RX   DOI=10.1007/s12374-011-9145-z;
RA   Chung M.S., Huang P., Ha C.M., Jun J.H., Ahn S.J., Zhang F.C., Bae H.J.,
RA   Cho B.H., Kim C.S.;
RT   "Molecular identification and physiological characterization of a putative
RT   novel plasma membrane protein from Arabidopsis involved in glucose
RT   response.";
RL   J. Plant Biol. 54:57-64(2011).
RN   [7]
RP   INDUCTION BY STKL1 AND STKL2.
RX   PubMed=27031427; DOI=10.1016/j.plaphy.2016.03.029;
RA   Chung M.S., Lee S., Min J.H., Huang P., Ju H.W., Kim C.S.;
RT   "Regulation of Arabidopsis thaliana plasma membrane glucose-responsive
RT   regulator (AtPGR) expression by A. thaliana storekeeper-like transcription
RT   factor, AtSTKL, modulates glucose response in Arabidopsis.";
RL   Plant Physiol. Biochem. 104:155-164(2016).
CC   -!- FUNCTION: Involved in the glucose-triggered developmental leaf growth
CC       process. {ECO:0000269|Ref.6}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|Ref.6}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Expressed in the vasculature of leaves, roots,
CC       inflorescences, siliques, anther filaments and sepals. Detected
CC       primarily in the phloem tissues, including in the root ans shoot apical
CC       meristems. {ECO:0000269|Ref.6}.
CC   -!- INDUCTION: Up-regulated by glucose (Ref.6). Down-regulated by STKL1 and
CC       STKL2 (PubMed:27031427). {ECO:0000269|PubMed:27031427,
CC       ECO:0000269|Ref.6}.
CC   -!- SIMILARITY: Belongs to the TMEM19 family. {ECO:0000305}.
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DR   EMBL; AF296836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002688; AED92767.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED92768.1; -; Genomic_DNA.
DR   EMBL; AK229183; BAF01053.1; -; mRNA.
DR   EMBL; AY085046; AAM61603.1; -; mRNA.
DR   RefSeq; NP_001190343.1; NM_001203414.2.
DR   RefSeq; NP_568386.1; NM_122000.4.
DR   AlphaFoldDB; Q0WP96; -.
DR   IntAct; Q0WP96; 5.
DR   STRING; 3702.AT5G19930.1; -.
DR   PaxDb; Q0WP96; -.
DR   PRIDE; Q0WP96; -.
DR   ProteomicsDB; 236789; -.
DR   EnsemblPlants; AT5G19930.1; AT5G19930.1; AT5G19930.
DR   EnsemblPlants; AT5G19930.2; AT5G19930.2; AT5G19930.
DR   GeneID; 832115; -.
DR   Gramene; AT5G19930.1; AT5G19930.1; AT5G19930.
DR   Gramene; AT5G19930.2; AT5G19930.2; AT5G19930.
DR   KEGG; ath:AT5G19930; -.
DR   Araport; AT5G19930; -.
DR   TAIR; locus:2147705; AT5G19930.
DR   eggNOG; KOG4491; Eukaryota.
DR   HOGENOM; CLU_036918_3_1_1; -.
DR   InParanoid; Q0WP96; -.
DR   OMA; VISPWRW; -.
DR   OrthoDB; 1476886at2759; -.
DR   PhylomeDB; Q0WP96; -.
DR   PRO; PR:Q0WP96; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q0WP96; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002794; DUF92_TMEM19.
DR   PANTHER; PTHR13353; PTHR13353; 1.
DR   Pfam; PF01940; DUF92; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..288
FT                   /note="Protein PGR"
FT                   /id="PRO_0000435964"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        216
FT                   /note="S -> F (in Ref. 4; AAM61603)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   288 AA;  30518 MW;  3A9E11FC93557451 CRC64;
     METSPQFRLI FAVIISSLIA FRSYKRKSLD LSGGIAGFLV MTIHFTAGFR YGALLLVFFL
     TSSKLTKVGE DKKRRVDVEF KEGGQRNWVQ VLCNSGIASV LVVIACTLTG WKDKCLDSKQ
     SEIVTALIGG IIGHYACCNG DTWSSELGVL SDAQPRLITT FKPVKKGTNG GVTKAGLLAA
     LAAGTTVGLT FLIFGLFTAS CASDVALKQL LVIPLSALAG LCGSLIDSIL GATIQFSGFC
     SVRNKVVGKP GPTVKKISGV DILDNNGVNF VSILLTSFLT SIASVYIF
 
 
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