PGR_ARATH
ID PGR_ARATH Reviewed; 288 AA.
AC Q0WP96; Q8LF53;
DT 13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Protein PGR {ECO:0000303|Ref.6};
DE Short=AtPGR {ECO:0000303|Ref.6};
DE AltName: Full=Plasma membrane glucose-responsive regulator {ECO:0000303|Ref.6};
DE AltName: Full=Transmembrane protein 19-like protein {ECO:0000305};
DE AltName: Full=VTE6-related protein {ECO:0000303|PubMed:26452599};
DE Short=VTE6R {ECO:0000303|PubMed:26452599};
GN Name=PGR {ECO:0000303|Ref.6};
GN OrderedLocusNames=At5g19930 {ECO:0000312|Araport:AT5G19930};
GN ORFNames=F28I16.80 {ECO:0000305};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:BAF01053.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=26452599; DOI=10.1105/tpc.15.00395;
RA Vom Dorp K., Hoelzl G., Plohmann C., Eisenhut M., Abraham M., Weber A.P.,
RA Hanson A.D., Doermann P.;
RT "Remobilization of phytol from chlorophyll degradation is essential for
RT tocopherol synthesis and growth of Arabidopsis.";
RL Plant Cell 27:2846-2859(2015).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION BY
RP GLUCOSE.
RX DOI=10.1007/s12374-011-9145-z;
RA Chung M.S., Huang P., Ha C.M., Jun J.H., Ahn S.J., Zhang F.C., Bae H.J.,
RA Cho B.H., Kim C.S.;
RT "Molecular identification and physiological characterization of a putative
RT novel plasma membrane protein from Arabidopsis involved in glucose
RT response.";
RL J. Plant Biol. 54:57-64(2011).
RN [7]
RP INDUCTION BY STKL1 AND STKL2.
RX PubMed=27031427; DOI=10.1016/j.plaphy.2016.03.029;
RA Chung M.S., Lee S., Min J.H., Huang P., Ju H.W., Kim C.S.;
RT "Regulation of Arabidopsis thaliana plasma membrane glucose-responsive
RT regulator (AtPGR) expression by A. thaliana storekeeper-like transcription
RT factor, AtSTKL, modulates glucose response in Arabidopsis.";
RL Plant Physiol. Biochem. 104:155-164(2016).
CC -!- FUNCTION: Involved in the glucose-triggered developmental leaf growth
CC process. {ECO:0000269|Ref.6}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|Ref.6}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in the vasculature of leaves, roots,
CC inflorescences, siliques, anther filaments and sepals. Detected
CC primarily in the phloem tissues, including in the root ans shoot apical
CC meristems. {ECO:0000269|Ref.6}.
CC -!- INDUCTION: Up-regulated by glucose (Ref.6). Down-regulated by STKL1 and
CC STKL2 (PubMed:27031427). {ECO:0000269|PubMed:27031427,
CC ECO:0000269|Ref.6}.
CC -!- SIMILARITY: Belongs to the TMEM19 family. {ECO:0000305}.
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DR EMBL; AF296836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED92767.1; -; Genomic_DNA.
DR EMBL; CP002688; AED92768.1; -; Genomic_DNA.
DR EMBL; AK229183; BAF01053.1; -; mRNA.
DR EMBL; AY085046; AAM61603.1; -; mRNA.
DR RefSeq; NP_001190343.1; NM_001203414.2.
DR RefSeq; NP_568386.1; NM_122000.4.
DR AlphaFoldDB; Q0WP96; -.
DR IntAct; Q0WP96; 5.
DR STRING; 3702.AT5G19930.1; -.
DR PaxDb; Q0WP96; -.
DR PRIDE; Q0WP96; -.
DR ProteomicsDB; 236789; -.
DR EnsemblPlants; AT5G19930.1; AT5G19930.1; AT5G19930.
DR EnsemblPlants; AT5G19930.2; AT5G19930.2; AT5G19930.
DR GeneID; 832115; -.
DR Gramene; AT5G19930.1; AT5G19930.1; AT5G19930.
DR Gramene; AT5G19930.2; AT5G19930.2; AT5G19930.
DR KEGG; ath:AT5G19930; -.
DR Araport; AT5G19930; -.
DR TAIR; locus:2147705; AT5G19930.
DR eggNOG; KOG4491; Eukaryota.
DR HOGENOM; CLU_036918_3_1_1; -.
DR InParanoid; Q0WP96; -.
DR OMA; VISPWRW; -.
DR OrthoDB; 1476886at2759; -.
DR PhylomeDB; Q0WP96; -.
DR PRO; PR:Q0WP96; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q0WP96; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR002794; DUF92_TMEM19.
DR PANTHER; PTHR13353; PTHR13353; 1.
DR Pfam; PF01940; DUF92; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..288
FT /note="Protein PGR"
FT /id="PRO_0000435964"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 216
FT /note="S -> F (in Ref. 4; AAM61603)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 288 AA; 30518 MW; 3A9E11FC93557451 CRC64;
METSPQFRLI FAVIISSLIA FRSYKRKSLD LSGGIAGFLV MTIHFTAGFR YGALLLVFFL
TSSKLTKVGE DKKRRVDVEF KEGGQRNWVQ VLCNSGIASV LVVIACTLTG WKDKCLDSKQ
SEIVTALIGG IIGHYACCNG DTWSSELGVL SDAQPRLITT FKPVKKGTNG GVTKAGLLAA
LAAGTTVGLT FLIFGLFTAS CASDVALKQL LVIPLSALAG LCGSLIDSIL GATIQFSGFC
SVRNKVVGKP GPTVKKISGV DILDNNGVNF VSILLTSFLT SIASVYIF