ID   PGS1_CANLF              Reviewed;         369 AA.
AC   O02678;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Biglycan;
DE   AltName: Full=Bone/cartilage proteoglycan I;
DE   AltName: Full=PG-S1;
DE   Flags: Precursor;
GN   Name=BGN;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Glant T.T.;
RT   "Complete coding sequence of canine biglycan.";
RL   Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in collagen fiber assembly. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Forms a ternary complex with MFAP2 and ELN (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250}.
CC   -!- PTM: The two attached glycosaminoglycan chains can be either
CC       chondroitin sulfate or dermatan sulfate. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC       family. SLRP class I subfamily. {ECO:0000305}.
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DR   EMBL; U83140; AAB51244.1; -; mRNA.
DR   RefSeq; NP_001003229.1; NM_001003229.1.
DR   AlphaFoldDB; O02678; -.
DR   SMR; O02678; -.
DR   STRING; 9612.ENSCAFP00000028297; -.
DR   CPTAC; CPTAC-3273; -.
DR   CPTAC; CPTAC-3278; -.
DR   PaxDb; O02678; -.
DR   PRIDE; O02678; -.
DR   GeneID; 403905; -.
DR   KEGG; cfa:403905; -.
DR   CTD; 633; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   InParanoid; O02678; -.
DR   OrthoDB; 826997at2759; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR028547; Biglycan.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   InterPro; IPR016352; SLRP_I_decor/aspor/byglycan.
DR   PANTHER; PTHR45712:SF11; PTHR45712:SF11; 1.
DR   Pfam; PF13855; LRR_8; 3.
DR   Pfam; PF01462; LRRNT; 1.
DR   PIRSF; PIRSF002490; SLRP_I; 1.
DR   SMART; SM00369; LRR_TYP; 8.
DR   SMART; SM00013; LRRNT; 1.
DR   PROSITE; PS51450; LRR; 8.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Extracellular matrix; Glycoprotein; Leucine-rich repeat;
KW   Proteoglycan; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000250|UniProtKB:P47853"
FT   PROPEP          17..37
FT                   /evidence="ECO:0000250|UniProtKB:P21810"
FT                   /id="PRO_0000032687"
FT   CHAIN           38..369
FT                   /note="Biglycan"
FT                   /id="PRO_0000032688"
FT   REPEAT          83..103
FT                   /note="LRR 1"
FT   REPEAT          104..127
FT                   /note="LRR 2"
FT   REPEAT          128..151
FT                   /note="LRR 3"
FT   REPEAT          152..172
FT                   /note="LRR 4"
FT   REPEAT          173..196
FT                   /note="LRR 5"
FT   REPEAT          197..221
FT                   /note="LRR 6"
FT   REPEAT          222..242
FT                   /note="LRR 7"
FT   REPEAT          243..266
FT                   /note="LRR 8"
FT   REPEAT          267..290
FT                   /note="LRR 9"
FT   REPEAT          291..313
FT                   /note="LRR 10"
FT   REPEAT          314..343
FT                   /note="LRR 11"
FT   REPEAT          344..369
FT                   /note="LRR 12"
FT   CARBOHYD        42
FT                   /note="O-linked (Xyl...) (glycosaminoglycan) serine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        48
FT                   /note="O-linked (Xyl...) (glycosaminoglycan) serine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        271
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        312
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        64..70
FT                   /evidence="ECO:0000250"
FT   DISULFID        68..77
FT                   /evidence="ECO:0000250"
FT   DISULFID        322..355
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   369 AA;  41566 MW;  8C919E922D6377E6 CRC64;
     MWPLWLVASL LALSQALPFE QKGFWDFTLD DGLPMLNDEE ASGAETTSGV PDLDALTPTY
     SAMCPFGCHC HLRVVQCSDL GLKAVPKEIS PDTMLLDLQN NDISELRADD FKGLHHLYAL
     VLVNNKISKI HEKAFSPLRK LQKLYISKNH LVEIPPNLPS SLVELRIHDN RIRKVPKGVF
     SGLRNMNCIE MGGNPLENSG FEPGAFDGLK LNYLRISEAK LTGIPKDLPE TLNELHLDHN
     KIQAIELEDL LRYSKLYRLG LGHNQIRMIE NGSLSFLPTL RELHLDNNKL SRVPSGLPDL
     KLLQVVYLHT NNITKVGVND FCPVGFGVKR AYYNGISLFN NPVPYWEVQP ATFRCVTDRL
     AIQFGNYKK