ID   PGS1_PIG                Reviewed;         272 AA.
AC   Q9GKQ6; Q9TTB5;
DT   20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2002, sequence version 2.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Biglycan;
DE   AltName: Full=Bone/cartilage proteoglycan I;
DE   AltName: Full=PG-S1;
DE   Flags: Precursor; Fragments;
GN   Name=BGN;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-137.
RC   TISSUE=Aorta;
RA   Zhao B.;
RL   Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 138-272.
RC   TISSUE=Skin;
RA   Wang J.F., Boykiw R.H., Reno C.R., Olson M.E., Hart D.A.;
RT   "Cloning and sequencing of porcine matrix molecules.";
RL   Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in collagen fiber assembly. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Forms a ternary complex with MFAP2 and ELN (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Found in several connective tissues, especially in
CC       articular cartilages.
CC   -!- PTM: The two attached glycosaminoglycan chains can be either
CC       chondroitin sulfate or dermatan sulfate. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC       family. SLRP class I subfamily. {ECO:0000305}.
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DR   EMBL; AF159382; AAF19153.1; -; mRNA.
DR   AlphaFoldDB; Q9GKQ6; -.
DR   SMR; Q9GKQ6; -.
DR   PeptideAtlas; Q9GKQ6; -.
DR   PRIDE; Q9GKQ6; -.
DR   InParanoid; Q9GKQ6; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR028547; Biglycan.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   PANTHER; PTHR45712:SF11; PTHR45712:SF11; 2.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF01462; LRRNT; 1.
DR   SMART; SM00369; LRR_TYP; 5.
DR   SMART; SM00013; LRRNT; 1.
DR   PROSITE; PS51450; LRR; 5.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Extracellular matrix; Glycoprotein; Leucine-rich repeat;
KW   Proteoglycan; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000250|UniProtKB:P47853"
FT   PROPEP          17..37
FT                   /evidence="ECO:0000250|UniProtKB:P21810"
FT                   /id="PRO_0000032695"
FT   CHAIN           38..272
FT                   /note="Biglycan"
FT                   /id="PRO_0000032696"
FT   DOMAIN          55..91
FT                   /note="LRRNT"
FT   REPEAT          92..113
FT                   /note="LRR 1"
FT   REPEAT          116..>137
FT                   /note="LRR 2"
FT   REPEAT          138..161
FT                   /note="LRR 3"
FT   REPEAT          162..183
FT                   /note="LRR 4"
FT   REPEAT          186..209
FT                   /note="LRR 5"
FT   REPEAT          210..232
FT                   /note="LRR 6"
FT   REPEAT          233..254
FT                   /note="LRR 7"
FT   REPEAT          255..>272
FT                   /note="LRR 8"
FT   CARBOHYD        42
FT                   /note="O-linked (Xyl...) (glycosaminoglycan) serine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        48
FT                   /note="O-linked (Xyl...) (glycosaminoglycan) serine"
FT                   /evidence="ECO:0000250"
FT   DISULFID        64..70
FT                   /evidence="ECO:0000250"
FT   DISULFID        68..77
FT                   /evidence="ECO:0000250"
FT   NON_CONS        137..138
FT                   /evidence="ECO:0000305"
FT   NON_TER         272
SQ   SEQUENCE   272 AA;  30457 MW;  6EBBAD0EF86378BB CRC64;
     MWPLWLLASL LALSQALPFE QKAFWDFTLD DGLPMLNDEE ASGADSTSGI PDLDALPPTF
     SAMCPFGCHC HLRVVQCSDL GLKAVPKEIS PDTTLLDLQN NDISELRKDD FKGLQHLYAL
     VLVNNKISRS TRRPSAPDGL KLNYLRISEA KLTGIPKDLP ETLNELHLDH NKIQAIELED
     LLRYSKLYRL GLGHNQIRMI ENGSLSFLPT LRELHLDNNK LSRVPAGLPD LKLLQVVYLH
     TNNITKVGVN DFCPVGFGVK RAYYNGISLF NN