ID   PGS1_XENLA              Reviewed;         368 AA.
AC   Q9IB75;
DT   20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Biglycan;
DE   Flags: Precursor;
GN   Name=bgn;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Goto T., Kubota H.Y.;
RT   "cDNA of biglycan of Xenopus laevis.";
RL   Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in collagen fiber assembly. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC       family. SLRP class I subfamily. {ECO:0000305}.
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DR   EMBL; AB037269; BAA90246.1; -; mRNA.
DR   RefSeq; NP_001084178.1; NM_001090709.1.
DR   AlphaFoldDB; Q9IB75; -.
DR   SMR; Q9IB75; -.
DR   GeneID; 399351; -.
DR   CTD; 399351; -.
DR   Xenbase; XB-GENE-17331698; bgn.L.
DR   OrthoDB; 826997at2759; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   Bgee; 399351; Expressed in camera-type eye and 17 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR028547; Biglycan.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   InterPro; IPR016352; SLRP_I_decor/aspor/byglycan.
DR   PANTHER; PTHR45712:SF11; PTHR45712:SF11; 1.
DR   Pfam; PF13855; LRR_8; 3.
DR   Pfam; PF01462; LRRNT; 1.
DR   PIRSF; PIRSF002490; SLRP_I; 1.
DR   SMART; SM00369; LRR_TYP; 8.
DR   SMART; SM00013; LRRNT; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Extracellular matrix; Glycoprotein; Leucine-rich repeat;
KW   Proteoglycan; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000250|UniProtKB:P47853"
FT   PROPEP          17..37
FT                   /evidence="ECO:0000250|UniProtKB:P21810"
FT                   /id="PRO_0000032701"
FT   CHAIN           38..368
FT                   /note="Biglycan"
FT                   /id="PRO_0000032702"
FT   REPEAT          82..102
FT                   /note="LRR 1"
FT   REPEAT          103..126
FT                   /note="LRR 2"
FT   REPEAT          127..150
FT                   /note="LRR 3"
FT   REPEAT          151..171
FT                   /note="LRR 4"
FT   REPEAT          172..195
FT                   /note="LRR 5"
FT   REPEAT          196..220
FT                   /note="LRR 6"
FT   REPEAT          221..241
FT                   /note="LRR 7"
FT   REPEAT          242..265
FT                   /note="LRR 8"
FT   REPEAT          266..289
FT                   /note="LRR 9"
FT   REPEAT          290..312
FT                   /note="LRR 10"
FT   REPEAT          313..342
FT                   /note="LRR 11"
FT   REPEAT          343..368
FT                   /note="LRR 12"
FT   CARBOHYD        270
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        311
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        63..69
FT                   /evidence="ECO:0000250"
FT   DISULFID        67..76
FT                   /evidence="ECO:0000250"
FT   DISULFID        321..354
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   368 AA;  41197 MW;  53ADF7E7E3BDC528 CRC64;
     MKVLLLLCSC ILVIHALPFE QRGFWDFSMD DGMAMMKDEE ASGVGPIPTE SIPDVGLPPM
     DLCPFGCQCH LRVVQCSDLG LTSIPKNLPK DTTLLDLQNN KITEIKKDDF KGLTNLYALV
     IVNNKISKIN EKAFEPLQKM QKLYISKNNL EEIPKNLPKS LVELRIHENK IKKVPKGVFS
     GLKNMNCIEM GGNPLENGGI EAGAFDGLKL NYLRVSEAKL SGIPKGLPST LNELHLDNNK
     IQAIEKEDLS QYASLYRLGL GHNNIRMIEN GSLSFMPVLR ELHLDNNKLS KVPPGLPDMK
     LLQVVYLHSN NITQVGVNDF CPIGFGVKRA YYNGISLFNN PVPYWEVQPA TFRCVTDRLA
     IQFGNYRK