ID   A4_VACCC                Reviewed;         281 AA.
AC   P20983;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   23-FEB-2022, entry version 54.
DE   RecName: Full=39kDa core protein;
DE            Short=p39;
DE   AltName: Full=Protein A4;
GN   ORFNames=A4L;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Component of the virion core. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with P4A/A10 and its cleaved form 4A. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Localizes between the
CC       core and the membrane; might surround the outer core wall like a
CC       palisade (spikes). {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- PTM: Its phosphorylation state is regulated by the F10 kinase and the
CC       H1 phosphatase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A4 family. {ECO:0000305}.
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DR   EMBL; M35027; AAA48120.1; -; Genomic_DNA.
DR   PIR; F42517; F42517.
DR   SMR; P20983; -.
DR   Proteomes; UP000008269; Genome.
DR   InterPro; IPR010396; Orthopox_A5.
DR   Pfam; PF06193; Orthopox_A5L; 1.
PE   2: Evidence at transcript level;
KW   Late protein; Reference proteome; Virion.
FT   CHAIN           1..281
FT                   /note="39kDa core protein"
FT                   /id="PRO_0000099218"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          91..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          149..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..112
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   281 AA;  30846 MW;  895EA02758FB8B50 CRC64;
     MDFFNKFSQG LAESSTPKSS IYYSEEKDPD TKKDEAIEIG LKSQESYYQR QLREQLARDN
     MMAASRQPIQ PLQPTIHITP QPVPTATPAP ILLPSSTAPT PKPRQQTNTS SDMSNLFDWL
     SEDTDAPASS LLPALTPSNA VQDIISKFNK DQKTTTPPST QPSQTLPTTT CTQQSDGNIS
     CTTPTVTPPQ PPIVATVCTP TPTGGTVCTT AQQNPNPGAA SQQNLDDMAL KDLMSSVEKD
     MHQLQAETND LVTNVYDARE YTRRAIDQIL QLVKGFERFQ K