ID   PGTA_DICDI              Reviewed;         311 AA.
AC   Q55DQ4;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Geranylgeranyl transferase type-2 subunit alpha;
DE            EC=2.5.1.60;
DE   AltName: Full=GGTase-II-alpha;
DE   AltName: Full=Geranylgeranyl transferase type II subunit alpha;
DE   AltName: Full=PGGT;
DE   AltName: Full=Type II protein geranyl-geranyltransferase subunit alpha;
GN   Name=rabggta; ORFNames=DDB_G0269570;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Catalyzes the transfer of a geranylgeranyl moiety from
CC       geranylgeranyl diphosphate to proteins with a C-terminal sequence motif
CC       -XCC or -XCXC, where both cysteines may become modified. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=geranylgeranyl diphosphate + L-cysteinyl-[protein] =
CC         diphosphate + S-geranylgeranyl-L-cysteinyl-[protein];
CC         Xref=Rhea:RHEA:21240, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11537,
CC         ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:57533,
CC         ChEBI:CHEBI:86021; EC=2.5.1.60;
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the protein prenyltransferase subunit alpha
CC       family. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL72135.2; -; Genomic_DNA.
DR   RefSeq; XP_646077.2; XM_640985.2.
DR   AlphaFoldDB; Q55DQ4; -.
DR   SMR; Q55DQ4; -.
DR   STRING; 44689.DDB0233950; -.
DR   PaxDb; Q55DQ4; -.
DR   EnsemblProtists; EAL72135; EAL72135; DDB_G0269570.
DR   GeneID; 8617027; -.
DR   KEGG; ddi:DDB_G0269570; -.
DR   dictyBase; DDB_G0269570; rabggta.
DR   eggNOG; KOG0529; Eukaryota.
DR   HOGENOM; CLU_031996_0_0_1; -.
DR   InParanoid; Q55DQ4; -.
DR   OMA; EYYTVWN; -.
DR   PhylomeDB; Q55DQ4; -.
DR   Reactome; R-DDI-6803205; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.
DR   Reactome; R-DDI-8873719; RAB geranylgeranylation.
DR   PRO; PR:Q55DQ4; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005968; C:Rab-protein geranylgeranyltransferase complex; ISS:UniProtKB.
DR   GO; GO:0004663; F:Rab geranylgeranyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0031267; F:small GTPase binding; ISS:UniProtKB.
DR   GO; GO:0018344; P:protein geranylgeranylation; ISS:UniProtKB.
DR   InterPro; IPR002088; Prenyl_trans_a.
DR   InterPro; IPR032955; RabGGTase_alpha.
DR   PANTHER; PTHR11129:SF2; PTHR11129:SF2; 1.
DR   Pfam; PF01239; PPTA; 5.
DR   PROSITE; PS51147; PFTA; 5.
PE   3: Inferred from homology;
KW   Coiled coil; Prenyltransferase; Reference proteome; Repeat; Transferase.
FT   CHAIN           1..311
FT                   /note="Geranylgeranyl transferase type-2 subunit alpha"
FT                   /id="PRO_0000331287"
FT   REPEAT          49..82
FT                   /note="PFTA 1"
FT   REPEAT          93..126
FT                   /note="PFTA 2"
FT   REPEAT          129..162
FT                   /note="PFTA 3"
FT   REPEAT          164..197
FT                   /note="PFTA 4"
FT   REPEAT          206..239
FT                   /note="PFTA 5"
FT   COILED          12..43
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   311 AA;  37779 MW;  F6640179FFC4DC41 CRC64;
     MHGVLKVRTS EEKAKAQRLK ELEKIESYNK LVKSFEELRE KQNGRYDEIS LSVSKLVLIE
     NPEFYTIWNY RRLAILQFTE TKENSELQVI YQNEMKFLEE CIQRFTKSYW IWFHRQWIAL
     RMDNCDWERE MKLCTKLLNF DLRNFHCWGH RRFILKHSNI KLEDELKYTT EKVEQNFSNY
     SAWHQRSSIL PKIYKEPEQL LEKILEEFEL VRNAVYTEPK DSSSWIYHKW LVATIKSIPN
     SNYIEVLKNE LTQIYDLIEL EPDCKWPIYT TLLLKIEIGG FEKQELLDII SQLIKLDPDH
     KNYYKSLETK I