PGTA_SCHPO
ID PGTA_SCHPO Reviewed; 344 AA.
AC O94412;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Geranylgeranyl transferase type-2 subunit alpha;
DE EC=2.5.1.60;
DE AltName: Full=GGTase-II-alpha;
DE AltName: Full=Geranylgeranyl transferase type II subunit alpha;
DE AltName: Full=PGGT;
DE AltName: Full=Type II protein geranyl-geranyltransferase subunit alpha;
GN Name=bet4; ORFNames=SPCC1620.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Catalyzes the transfer of a geranyl-geranyl moiety from
CC geranyl-geranyl pyrophosphate to proteins having the C-terminal-XCC or
CC -XCXC, where both cysteines may become modified. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=geranylgeranyl diphosphate + L-cysteinyl-[protein] =
CC diphosphate + S-geranylgeranyl-L-cysteinyl-[protein];
CC Xref=Rhea:RHEA:21240, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11537,
CC ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:57533,
CC ChEBI:CHEBI:86021; EC=2.5.1.60;
CC -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the protein prenyltransferase subunit alpha
CC family. {ECO:0000305}.
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DR EMBL; CU329672; CAA22489.1; -; Genomic_DNA.
DR PIR; T41035; T41035.
DR RefSeq; NP_588463.1; NM_001023454.2.
DR AlphaFoldDB; O94412; -.
DR SMR; O94412; -.
DR BioGRID; 275909; 1.
DR STRING; 4896.SPCC1620.05.1; -.
DR MaxQB; O94412; -.
DR PaxDb; O94412; -.
DR EnsemblFungi; SPCC1620.05.1; SPCC1620.05.1:pep; SPCC1620.05.
DR GeneID; 2539343; -.
DR KEGG; spo:SPCC1620.05; -.
DR PomBase; SPCC1620.05; bet4.
DR VEuPathDB; FungiDB:SPCC1620.05; -.
DR eggNOG; KOG0529; Eukaryota.
DR HOGENOM; CLU_031996_0_0_1; -.
DR InParanoid; O94412; -.
DR OMA; EYYTVWN; -.
DR PhylomeDB; O94412; -.
DR Reactome; R-SPO-6803205; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.
DR Reactome; R-SPO-8873719; RAB geranylgeranylation.
DR PRO; PR:O94412; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0044732; C:mitotic spindle pole body; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005968; C:Rab-protein geranylgeranyltransferase complex; ISS:UniProtKB.
DR GO; GO:0004663; F:Rab geranylgeranyltransferase activity; ISS:UniProtKB.
DR GO; GO:0031267; F:small GTPase binding; ISS:UniProtKB.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISO:PomBase.
DR GO; GO:0018344; P:protein geranylgeranylation; ISS:UniProtKB.
DR GO; GO:0072659; P:protein localization to plasma membrane; IC:PomBase.
DR InterPro; IPR002088; Prenyl_trans_a.
DR InterPro; IPR032955; RabGGTase_alpha.
DR PANTHER; PTHR11129:SF2; PTHR11129:SF2; 1.
DR Pfam; PF01239; PPTA; 5.
DR PROSITE; PS51147; PFTA; 6.
PE 3: Inferred from homology;
KW Prenyltransferase; Reference proteome; Repeat; Transferase.
FT CHAIN 1..344
FT /note="Geranylgeranyl transferase type-2 subunit alpha"
FT /id="PRO_0000314652"
FT REPEAT 44..78
FT /note="PFTA 1"
FT REPEAT 89..123
FT /note="PFTA 2"
FT REPEAT 125..159
FT /note="PFTA 3"
FT REPEAT 165..199
FT /note="PFTA 4"
FT REPEAT 214..248
FT /note="PFTA 5"
FT REPEAT 266..293
FT /note="PFTA 6"
SQ SEQUENCE 344 AA; 41194 MW; 6801D2872013427F CRC64;
MHGILRVKLS EEQRKLKAEK ERAKIEEYRG LVSRFQEARK RKDYSEGNLK LTTELLDWNP
ETYSVWNYRR EILLNDVFPK ISLNEKQDLL DNELKYVLSK MKVFPKVYWI FNHRRWCLEN
APYPNWNYEM MITEKLLSAD ARNFHGWHYR RYVVSQIERA GNCSLAKKEM EYTTSAIATN
FSNFSALHNR TKLIETILNL EADPNSQKAL AKQILEQELD MIHQAVFTDP DDSSVWIYHR
WLMGHCNPNS MTPLISMITI EERIQYLQKE IELIQELHEM EPENRWCCES LVNYEALCKT
LEKQKPTEAD IKRWTLLVDK MIKVDPQRRG RYRTLQEKIN NLNK
