PGTP_SALTY
ID PGTP_SALTY Reviewed; 463 AA.
AC P12681;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Phosphoglycerate transporter protein;
GN Name=pgtP; OrderedLocusNames=STM2399;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-458.
RX PubMed=3042749; DOI=10.1128/jb.170.8.3421-3426.1988;
RA Goldrick D., Yu G.-Q., Jiang S.-Q., Hong J.-S.;
RT "Nucleotide sequence and transcription start point of the phosphoglycerate
RT transporter gene of Salmonella typhimurium.";
RL J. Bacteriol. 170:3421-3426(1988).
CC -!- FUNCTION: The phosphoglycerate transporter protein is a part of the PGT
CC transport system. It is the membrane bound transporter for
CC phosphoglycerate into salmonella.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- INDUCTION: By extracellular phosphoglycerate.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA27186.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AE006468; AAL21299.1; -; Genomic_DNA.
DR EMBL; M21278; AAA27186.1; ALT_FRAME; Genomic_DNA.
DR PIR; A31089; JNEBPT.
DR RefSeq; NP_461340.1; NC_003197.2.
DR RefSeq; WP_000955748.1; NC_003197.2.
DR AlphaFoldDB; P12681; -.
DR SMR; P12681; -.
DR STRING; 99287.STM2399; -.
DR TCDB; 2.A.1.4.2; the major facilitator superfamily (mfs).
DR PaxDb; P12681; -.
DR EnsemblBacteria; AAL21299; AAL21299; STM2399.
DR GeneID; 1253921; -.
DR KEGG; stm:STM2399; -.
DR PATRIC; fig|99287.12.peg.2538; -.
DR HOGENOM; CLU_001265_31_0_6; -.
DR OMA; FITLANW; -.
DR PhylomeDB; P12681; -.
DR BioCyc; SENT99287:STM2399-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0061513; F:glucose 6-phosphate:inorganic phosphate antiporter activity; IBA:GO_Central.
DR GO; GO:0015760; P:glucose-6-phosphate transport; IBA:GO_Central.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR021159; Sugar-P_transporter_CS.
DR InterPro; IPR000849; Sugar_P_transporter.
DR Pfam; PF07690; MFS_1; 1.
DR PIRSF; PIRSF002808; Hexose_phosphate_transp; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS00942; GLPT; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..463
FT /note="Phosphoglycerate transporter protein"
FT /id="PRO_0000199880"
FT TOPO_DOM 1..29
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 254
FT /note="L -> V (in Ref. 2; AAA27186)"
FT /evidence="ECO:0000305"
FT CONFLICT 408
FT /note="V -> L (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 440
FT /note="A -> G (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 463 AA; 50999 MW; 32FE7B7E858B6B4B CRC64;
MLTILKTGQS AHKVPPEKVQ ATYGRYRIQA LLSVFLGYLA YYIVRNNFTL STPYLKEQLD
LSATQIGLLS SCMLIAYGIS KGVMSSLADK ASPKVFMACG LVLCAIVNVG LGFSSAFWIF
AALVVFNGLF QGMGVGPSFI TIANWFPRRE RGRVGAFWNI SHNVGGGIVA PIVGAAFAIL
GSEHWQSASY IVPACVAVIF ALIVLVLGKG SPRKEGLPSL EQMMPEEKVV LKTKNTAKAP
ENMSAWQIFC TYVLRNKNAW YISLVDVFVY MVRFGMISWL PIYLLTVKHF SKEQMSVAFL
FFEWAAIPST LLAGWLSDKL FKGRRMPLAM ICMALIFVCL IGYWKSESLL MVTIFAAIVG
CLIYVPQFLA SVQTMEIVPS FAVGSAVGLR GFMSYIFGAS LGTSLFGVMV DKLGWYGGFY
LLMGGIVCCI LFCYLSHRGA LELERQRQNA LHNQDSLQLA DAQ
