PH2AB_DICDI
ID PH2AB_DICDI Reviewed; 483 AA.
AC Q54Q99;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Serine/threonine-protein phosphatase 2A regulatory subunit phr2AB;
DE AltName: Full=Protein phosphatase 2A 55 kDa regulatory subunit;
DE AltName: Full=Protein phosphatase 2A B55 regulatory subunit;
DE AltName: Full=Protein phosphatase 2A PR55 regulatory subunit;
DE AltName: Full=Protein phosphatase 2A regulatory B subunit;
GN Name=phr2aB; Synonyms=pppD; ORFNames=DDB_G0283905;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP SUBCELLULAR LOCATION.
RX PubMed=18673380; DOI=10.1111/j.1432-0436.2008.00301.x;
RA Lee N.-S., Veeranki S., Kim B., Kim L.;
RT "The function of PP2A/B56 in non-metazoan multicellular development.";
RL Differentiation 76:1104-1110(2008).
CC -!- FUNCTION: The B regulatory subunit might modulate substrate selectivity
CC and catalytic activity, and also might direct the localization of the
CC catalytic enzyme to a particular subcellular compartment.
CC {ECO:0000305}.
CC -!- SUBUNIT: PP2A consists of a trimeric holoenzyme, composed of a 37 kDa
CC catalytic subunit (C subunit) and a 65 kDa constant regulatory subunit
CC (A subunit), that associates with a variety of regulatory subunits (B
CC subunit) such as phr2AB (B55) and psrA (B56 homolog). The trimer may
CC partially dissociates into a core 'AC' dimer equally active compared to
CC the trimer (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18673380}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000269|PubMed:18673380}.
CC -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000058; EAL65440.1; -; Genomic_DNA.
DR RefSeq; XP_638845.1; XM_633753.1.
DR AlphaFoldDB; Q54Q99; -.
DR SMR; Q54Q99; -.
DR STRING; 44689.DDB0191428; -.
DR PaxDb; Q54Q99; -.
DR PRIDE; Q54Q99; -.
DR EnsemblProtists; EAL65440; EAL65440; DDB_G0283905.
DR GeneID; 8624370; -.
DR KEGG; ddi:DDB_G0283905; -.
DR dictyBase; DDB_G0283905; phr2aB.
DR eggNOG; KOG1354; Eukaryota.
DR HOGENOM; CLU_021713_3_3_1; -.
DR InParanoid; Q54Q99; -.
DR OMA; HPISCNW; -.
DR PhylomeDB; Q54Q99; -.
DR Reactome; R-DDI-69231; Cyclin D associated events in G1.
DR Reactome; R-DDI-69273; Cyclin A/B1/B2 associated events during G2/M transition.
DR PRO; PR:Q54Q99; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0000159; C:protein phosphatase type 2A complex; IDA:dictyBase.
DR GO; GO:0017020; F:myosin phosphatase regulator activity; IDA:dictyBase.
DR GO; GO:0019888; F:protein phosphatase regulator activity; IDA:dictyBase.
DR GO; GO:0031034; P:myosin filament assembly; IDA:dictyBase.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR000009; PP2A_PR55.
DR InterPro; IPR018067; PP2A_PR55_CS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR11871; PTHR11871; 1.
DR PIRSF; PIRSF037309; PP2A_PR55; 1.
DR PRINTS; PR00600; PP2APR55.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS01024; PR55_1; 1.
DR PROSITE; PS01025; PR55_2; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Cytoskeleton; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..483
FT /note="Serine/threonine-protein phosphatase 2A regulatory
FT subunit phr2AB"
FT /id="PRO_0000367476"
FT REPEAT 22..61
FT /note="WD 1"
FT REPEAT 88..129
FT /note="WD 2"
FT REPEAT 206..244
FT /note="WD 3"
FT REPEAT 255..295
FT /note="WD 4"
FT REPEAT 314..352
FT /note="WD 5"
FT REPEAT 369..410
FT /note="WD 6"
FT REPEAT 449..483
FT /note="WD 7"
FT REGION 132..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..443
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 483 AA; 55205 MW; CC0AA02E034BACC8 CRC64;
MTEPLDWRFS QTFGGKGNED ASDANVVPAI EFDQTGDFIA VGDKGGKVLL LKRTHDKQSS
KKSKLPEYRF YSEFQSHEPE FDYLKSLEIE EKINKIKWCP KQNDAQFLLT TNDKTIKLWK
VYEKKIKQVS TSATTTGPSY NGSLASNNTR SPSHTTYIYN SSGAHNMNNN MNNSNNNNNL
NNFKIPKLTT RETVVTATPR KIFQNAHAYH INSISLNSDG ETYISSDDLR IHLWNLNINT
ECFNVVDIKP TNMEDLTEVI TSAEFHPTSC NIFMYSSSKG TIKLGDLRSS ALCDNHAKVF
EEYEDPSNKS FFSEIISSIS DIKFSRDGRY ILSRDFLTLK LWDINMENKP VKTIQIHDYL
KPKLCDLYEN DCIFDKFECT LNHDGTQMLT GSYHNYLHIY DRNSKQDVCL EASKQATKSK
TKTLTTKMKL RSSKKEPKKP EDIHPDAIEY TKKTLHCAWH PKDNLIAVGA ANTVYLYAAT
ENK
