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PHAAB_RHIME
ID   PHAAB_RHIME             Reviewed;         999 AA.
AC   Q52978; Q52979; Q8RTE9; Q92LV7;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 2.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Probable K(+)/H(+) antiporter subunit A/B;
DE   AltName: Full=pH adaptation potassium efflux system protein A/B;
DE            Short=Pha system subunit A/B;
GN   Name=phaAB; Synonyms=phaA, phaA1, phaB; OrderedLocusNames=R02910;
GN   ORFNames=SMc03179;
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=41;
RX   PubMed=9680201; DOI=10.1046/j.1365-2958.1998.00868.x;
RA   Putnoky P., Kereszt A., Nakamura T., Endre G., Grosskopf E., Kiss P.,
RA   Kondorosi A.;
RT   "The pha gene cluster of Rhizobium meliloti involved in pH adaptation and
RT   symbiosis encodes a novel type of K+ efflux system.";
RL   Mol. Microbiol. 28:1091-1101(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11481430; DOI=10.1073/pnas.161294398;
RA   Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA   Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA   Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA   Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA   Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT   "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT   meliloti strain 1021.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-926.
RC   STRAIN=JJ1c10;
RA   Watson R.J., Heys R.;
RT   "Sinorhizobium meliloti phaA gene segment.";
RL   Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of a K(+) efflux system which is required for the
CC       adaptation of R.meliloti to alkaline pH as well as for the infection
CC       process during symbiotic nodule development.
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of six
CC       subunits: PhaAB, PhaC, PhaD, PhaE, PhaF and PhaG.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the CPA3 antiporters
CC       (TC 2.A.63) subunit A family. {ECO:0000305}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the CPA3 antiporters
CC       (TC 2.A.63) subunit B family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA63735.1; Type=Frameshift; Note=Produces two separate ORFs named phaA and phaB.; Evidence={ECO:0000305};
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DR   EMBL; X93358; CAA63734.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; X93358; CAA63735.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AL591688; CAC47489.1; -; Genomic_DNA.
DR   EMBL; AF465791; AAL76258.1; -; Genomic_DNA.
DR   RefSeq; NP_387016.1; NC_003047.1.
DR   RefSeq; WP_010970284.1; NC_003047.1.
DR   AlphaFoldDB; Q52978; -.
DR   SMR; Q52978; -.
DR   STRING; 266834.SMc03179; -.
DR   TCDB; 2.A.63.1.1; the monovalent cation (k(+) or na(+)):proton antiporter-3 (cpa3) family.
DR   PRIDE; Q52978; -.
DR   EnsemblBacteria; CAC47489; CAC47489; SMc03179.
DR   GeneID; 61604370; -.
DR   KEGG; sme:SMc03179; -.
DR   PATRIC; fig|266834.11.peg.4431; -.
DR   eggNOG; COG1009; Bacteria.
DR   eggNOG; COG2111; Bacteria.
DR   HOGENOM; CLU_007100_2_0_5; -.
DR   OMA; AFILQYM; -.
DR   Proteomes; UP000001976; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005451; F:monovalent cation:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0098662; P:inorganic cation transmembrane transport; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005281; CPA3_sub_B.
DR   InterPro; IPR025383; MbhD-like_TM.
DR   InterPro; IPR007182; MnhB.
DR   InterPro; IPR005663; MrpA/MnhA1/PhaAB.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   Pfam; PF13244; DUF4040; 1.
DR   Pfam; PF04039; MnhB; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
DR   TIGRFAMs; TIGR00940; 2a6301s01; 1.
DR   TIGRFAMs; TIGR00943; 2a6301s02; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW   Potassium; Potassium transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..999
FT                   /note="Probable K(+)/H(+) antiporter subunit A/B"
FT                   /id="PRO_0000217075"
FT   TRANSMEM        31..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        336..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        442..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        488..510
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        530..552
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        604..621
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        636..653
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        660..682
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        686..708
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        729..751
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        788..807
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        846..868
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        878..900
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        913..935
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        955..977
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        122
FT                   /note="A -> V (in Ref. 1; CAA63734)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        188
FT                   /note="G -> A (in Ref. 1; CAA63734)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   999 AA;  108790 MW;  9857B829580C2286 CRC64;
     MTRPASVLAG PKSRPPIHSQ GDKTIEYAEK LLSVFILVPF AGSLIAIFFP SDQRGAISWF
     AGAIALVCFL VTAGLYPYVA SGGVLHYRID WVPELGLNFT LRMDGFAWLF SALITAIGVL
     VALYARYYMA EEDPVPRFFA LFLAFMGSML GVVLSGNLIL LAVFWELTSI VSFLLIGYWH
     HNAHARDGAR MALTITGTGG LAMFVGLIII GKIVGSYELD AVLASGDAIR NHPLYGTVLV
     LVLLGALTKS AQFPFHFWLP HAMAAPTPVS AYLHSATMVK AGVFLLVRFW PVMAGTEAWF
     WIVGLAGLTT LLLGAYFAIF QQDLKGLLAY STISHLGLIT VLLSLGSPLA AVAAVFHIVN
     HATFKASLFM AAGIIDHESG TRDIRRLGGL FHFMPITATL AMVASAAMAG VPLLNGFLSK
     EMFFAEAIET HLVNPLDTVT PYVATIAGMF AVTYSLRFIH GVFFGRPPAD LPRKPHEPPR
     WMRAPLDFLV LACLVVGIIP AQTIGPFLHT AVLSVLREGT PDYSLSVWHG WNIPLIMSFV
     ALSGGIGLYF LMRSYLATAV EGPPVFRLLQ GQRIFERVLV TLSWKWARWL EQRLGTRRLQ
     PQMRLLVFLA LAAGASPLLL GNFELPPLVI RGIDPAFALL WAIGIACAIG SAYQAKFHRL
     ASLVLLGGAG LVTCITFVWL SAPDLAVTQL LVEIVTTVLI LLGLRWLPKR IEEPVAAEDI
     SIRVRLRRLR DLLLAIGAGG GMMLIAYTVM TRPLPETIAS YFLERAYREG GGTNVVNVIL
     VDFRGFDTLG EIAVLCIVAL TVFALLLRFR PQSDSLEAPE QQKVQNAFDD DHPDRAAGDS
     VAEYLFIPAV IMRWMFPVTG MLAAFLFLRG HDLPGGGFAA GIAMSIGFIL QYMSGGTRWV
     EERLRIHPLR WMSIGLLVAT ATGVGSWFFG YPFLTSHAQY ASLPVVGKFP LASAILFDLG
     VFSLVLGATV LILIALAHQS VRAPRAHAKA ARSDKEAVR
 
 
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