ID   A4_VACCW                Reviewed;         281 AA.
AC   P29191; Q76ZQ9;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   23-FEB-2022, entry version 51.
DE   RecName: Full=39kDa core protein;
DE            Short=p39;
DE   AltName: Full=Protein A4;
GN   OrderedLocusNames=VACWR123; ORFNames=A4L;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1731116; DOI=10.1128/jvi.66.2.971-982.1992;
RA   Ahn B.-Y., Rosel J., Cole N.B., Moss B.;
RT   "Identification and expression of rpo19, a vaccinia virus gene encoding a
RT   19-kilodalton DNA-dependent RNA polymerase subunit.";
RL   J. Virol. 66:971-982(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   INDUCTION.
RX   PubMed=3316708; DOI=10.1128/jvi.61.12.3910-3919.1987;
RA   Maa J.S., Esteban M.;
RT   "Structural and functional studies of a 39,000-Mr immunodominant protein of
RT   vaccinia virus.";
RL   J. Virol. 61:3910-3919(1987).
RN   [4]
RP   INTERACTION WITH P4A/A10, AND SUBCELLULAR LOCATION.
RX   PubMed=10600608; DOI=10.1006/viro.1999.0046;
RA   Risco C., Rodriguez J.R., Demkowicz W., Heljasvaara R., Carrascosa J.L.,
RA   Esteban M., Rodriguez D.;
RT   "The vaccinia virus 39-kDa protein forms a stable complex with the p4a/4a
RT   major core protein early in morphogenesis.";
RL   Virology 265:375-386(1999).
CC   -!- FUNCTION: Component of the virion core.
CC   -!- SUBUNIT: Interacts with P4A/A10 and its cleaved form 4A.
CC       {ECO:0000269|PubMed:10600608}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:10600608}.
CC       Note=Localizes between the core and the membrane; might surround the
CC       outer core wall like a palisade (spikes).
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       {ECO:0000269|PubMed:3316708}.
CC   -!- PTM: Its phosphorylation state is regulated by the F10 kinase and the
CC       H1 phosphatase. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A4 family. {ECO:0000305}.
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DR   EMBL; M76473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY243312; AAO89402.1; -; Genomic_DNA.
DR   PIR; A41806; QQVZA5.
DR   RefSeq; YP_233005.1; NC_006998.1.
DR   SMR; P29191; -.
DR   DIP; DIP-2173N; -.
DR   IntAct; P29191; 1.
DR   MINT; P29191; -.
DR   GeneID; 3707521; -.
DR   KEGG; vg:3707521; -.
DR   Proteomes; UP000000344; Genome.
DR   InterPro; IPR010396; Orthopox_A5.
DR   Pfam; PF06193; Orthopox_A5L; 1.
PE   1: Evidence at protein level;
KW   Late protein; Reference proteome; Virion.
FT   CHAIN           1..281
FT                   /note="39kDa core protein"
FT                   /id="PRO_0000099219"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          93..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          149..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..112
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   281 AA;  30927 MW;  124AE6E52CB70BAE CRC64;
     MDFFNKFSQG LAESSTPKSS IYYSEEKDPD TKKDEAIEIG LKSQESYYQR QLREQLARDN
     MTVASRQPIQ PLQPTIHITP QPVPTATPAP ILLPSSTVPT PKPRQQTNTS SDMSNLFDWL
     SEDTDAPASS LLPALTPSNA VQDIISKFNK DQKTTTPPST QPSQTLPTTT CTQQSDGNIS
     CTTPTVTPPQ PPIVATVCTP TPTGGTVCTT AQQNPNPGAA SQQNLDDMAL KDLMSNVERD
     MHQLQAETND LVTNVYDARE YTRRAIDQIL QLVKGFERFQ K