ID   PHAC1_RHIME             Reviewed;         115 AA.
AC   Q52980;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Probable K(+)/H(+) antiporter subunit C;
DE   AltName: Full=pH adaptation potassium efflux system protein C;
DE            Short=Pha system subunit C;
GN   Name=phaC; Synonyms=phaC1; OrderedLocusNames=R02911; ORFNames=SMc03180;
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=41;
RX   PubMed=9680201; DOI=10.1046/j.1365-2958.1998.00868.x;
RA   Putnoky P., Kereszt A., Nakamura T., Endre G., Grosskopf E., Kiss P.,
RA   Kondorosi A.;
RT   "The pha gene cluster of Rhizobium meliloti involved in pH adaptation and
RT   symbiosis encodes a novel type of K+ efflux system.";
RL   Mol. Microbiol. 28:1091-1101(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11481430; DOI=10.1073/pnas.161294398;
RA   Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA   Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA   Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA   Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA   Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT   "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT   meliloti strain 1021.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
CC   -!- FUNCTION: Part of a K(+) efflux system which is required for the
CC       adaptation of R.meliloti to alkaline pH as well as for the infection
CC       process during symbiotic nodule development.
CC   -!- SUBUNIT: May form a hetero-oligomeric complex that consists of six
CC       subunits: PhaAB, PhaC, PhaD, PhaE, PhaF and PhaG.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit C
CC       family. {ECO:0000305}.
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DR   EMBL; X93358; CAA63736.1; -; Genomic_DNA.
DR   EMBL; AL591688; CAC47490.1; -; Genomic_DNA.
DR   RefSeq; NP_387017.1; NC_003047.1.
DR   RefSeq; WP_003528841.1; NC_003047.1.
DR   AlphaFoldDB; Q52980; -.
DR   SMR; Q52980; -.
DR   STRING; 266834.SMc03180; -.
DR   TCDB; 2.A.63.1.1; the monovalent cation (k(+) or na(+)):proton antiporter-3 (cpa3) family.
DR   EnsemblBacteria; CAC47490; CAC47490; SMc03180.
DR   GeneID; 61604371; -.
DR   KEGG; sme:SMc03180; -.
DR   PATRIC; fig|266834.11.peg.4432; -.
DR   eggNOG; COG1006; Bacteria.
DR   HOGENOM; CLU_082058_3_0_5; -.
DR   OMA; YRVYEEH; -.
DR   Proteomes; UP000001976; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR006673; Mnh_C1_su.
DR   InterPro; IPR039428; NUOK/Mnh_C1-like.
DR   Pfam; PF00420; Oxidored_q2; 1.
DR   TIGRFAMs; TIGR00941; 2a6301s03; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW   Potassium; Potassium transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..115
FT                   /note="Probable K(+)/H(+) antiporter subunit C"
FT                   /id="PRO_0000089156"
FT   TRANSMEM        4..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   115 AA;  12214 MW;  2125FB09B20BDF67 CRC64;
     MELILSAGIG TLTASGVYLL LRPRTYQVII GLSLLSFAVN LFIFGMGRLR VNAPPILDPG
     GVGDLARYTD PVPQALVLTA IVIGFAMTAL FLVVLLASRG FTGTDHVDGR EQRGD