PHAE_RHIME
ID PHAE_RHIME Reviewed; 161 AA.
AC Q52982;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Probable K(+)/H(+) antiporter subunit E;
DE AltName: Full=pH adaptation potassium efflux system protein E;
DE Short=Pha system subunit E;
GN Name=phaE; Synonyms=phaE1; OrderedLocusNames=R02913; ORFNames=SMc03182;
OS Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS meliloti).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=266834;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=41;
RX PubMed=9680201; DOI=10.1046/j.1365-2958.1998.00868.x;
RA Putnoky P., Kereszt A., Nakamura T., Endre G., Grosskopf E., Kiss P.,
RA Kondorosi A.;
RT "The pha gene cluster of Rhizobium meliloti involved in pH adaptation and
RT symbiosis encodes a novel type of K+ efflux system.";
RL Mol. Microbiol. 28:1091-1101(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11481430; DOI=10.1073/pnas.161294398;
RA Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT meliloti strain 1021.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11474104; DOI=10.1126/science.1060966;
RA Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA Wong K., Yeh K.-C., Batut J.;
RT "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL Science 293:668-672(2001).
CC -!- FUNCTION: Part of a K(+) efflux system which is required for the
CC adaptation of R.meliloti to alkaline pH as well as for the infection
CC process during symbiotic nodule development.
CC -!- SUBUNIT: May form a hetero-oligomeric complex that consists of six
CC subunits: PhaAB, PhaC, PhaD, PhaE, PhaF and PhaG.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E
CC family. {ECO:0000305}.
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DR EMBL; X93358; CAA63738.1; -; Genomic_DNA.
DR EMBL; AL591688; CAC47492.1; -; Genomic_DNA.
DR RefSeq; NP_387019.1; NC_003047.1.
DR RefSeq; WP_003528836.1; NC_003047.1.
DR AlphaFoldDB; Q52982; -.
DR SMR; Q52982; -.
DR STRING; 266834.SMc03182; -.
DR TCDB; 2.A.63.1.1; the monovalent cation (k(+) or na(+)):proton antiporter-3 (cpa3) family.
DR EnsemblBacteria; CAC47492; CAC47492; SMc03182.
DR GeneID; 61604373; -.
DR KEGG; sme:SMc03182; -.
DR PATRIC; fig|266834.11.peg.4434; -.
DR eggNOG; COG1863; Bacteria.
DR HOGENOM; CLU_086615_4_0_5; -.
DR OMA; NSFSAGH; -.
DR Proteomes; UP000001976; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR InterPro; IPR004847; Antiport_suE1.
DR InterPro; IPR002758; Cation_antiport_E.
DR PANTHER; PTHR34584; PTHR34584; 1.
DR Pfam; PF01899; MNHE; 1.
DR PIRSF; PIRSF019239; MrpE; 1.
DR TIGRFAMs; TIGR00942; 2a6301s05; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW Potassium; Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..161
FT /note="Probable K(+)/H(+) antiporter subunit E"
FT /id="PRO_0000217095"
FT TRANSMEM 4..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..50
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 161 AA; 18240 MW; 59F7F986C1929513 CRC64;
MRTWFPYPLL SIALLLMWLL LSQSVTPGSI VLGLVVSTVL AWVTLNLQPA RSRLHRWSRI
AGFILRVVGD VIRSNIAVTL IILRAGRRPV NAGFMTVSLD LDDENALALL ACVVTATPGT
AWLEYDRRQK ILLFHVLDIE NEDLWRKTIT RYAADLKEIF E
