PHAG_RHIME
ID PHAG_RHIME Reviewed; 121 AA.
AC Q9Z3Q3;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Probable K(+)/H(+) antiporter subunit G;
DE AltName: Full=pH adaptation potassium efflux system protein G;
DE Short=Pha system subunit G;
GN Name=phaG; Synonyms=phaG1; OrderedLocusNames=R02915; ORFNames=SMc03184;
OS Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS meliloti).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=266834;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=41;
RX PubMed=9680201; DOI=10.1046/j.1365-2958.1998.00868.x;
RA Putnoky P., Kereszt A., Nakamura T., Endre G., Grosskopf E., Kiss P.,
RA Kondorosi A.;
RT "The pha gene cluster of Rhizobium meliloti involved in pH adaptation and
RT symbiosis encodes a novel type of K+ efflux system.";
RL Mol. Microbiol. 28:1091-1101(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11481430; DOI=10.1073/pnas.161294398;
RA Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT meliloti strain 1021.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11474104; DOI=10.1126/science.1060966;
RA Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA Wong K., Yeh K.-C., Batut J.;
RT "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL Science 293:668-672(2001).
CC -!- FUNCTION: Part of a K(+) efflux system which is required for the
CC adaptation of R.meliloti to alkaline pH as well as for the infection
CC process during symbiotic nodule development.
CC -!- SUBUNIT: May form a hetero-oligomeric complex that consists of six
CC subunits: PhaAB, PhaC, PhaD, PhaE, PhaF and PhaG.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit G
CC family. {ECO:0000305}.
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DR EMBL; X93358; CAA63740.2; -; Genomic_DNA.
DR EMBL; AL591688; CAC47494.1; -; Genomic_DNA.
DR RefSeq; NP_387021.1; NC_003047.1.
DR RefSeq; WP_010970285.1; NC_003047.1.
DR AlphaFoldDB; Q9Z3Q3; -.
DR SMR; Q9Z3Q3; -.
DR STRING; 266834.SMc03184; -.
DR TCDB; 2.A.63.1.1; the monovalent cation (k(+) or na(+)):proton antiporter-3 (cpa3) family.
DR EnsemblBacteria; CAC47494; CAC47494; SMc03184.
DR GeneID; 61604375; -.
DR KEGG; sme:SMc03184; -.
DR PATRIC; fig|266834.11.peg.4436; -.
DR eggNOG; COG1320; Bacteria.
DR HOGENOM; CLU_121334_1_0_5; -.
DR OMA; FMTVTTP; -.
DR Proteomes; UP000001976; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005451; F:monovalent cation:proton antiporter activity; IEA:InterPro.
DR GO; GO:0098662; P:inorganic cation transmembrane transport; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR005133; PhaG_MnhG_YufB.
DR PANTHER; PTHR34703; PTHR34703; 1.
DR Pfam; PF03334; PhaG_MnhG_YufB; 1.
DR TIGRFAMs; TIGR01300; CPA3_mnhG_phaG; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW Potassium; Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..121
FT /note="Probable K(+)/H(+) antiporter subunit G"
FT /id="PRO_0000086865"
FT TRANSMEM 10..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..94
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 121 AA; 13220 MW; D3FEA84A5F77EFE9 CRC64;
MSHLTDLPPW AALLVCGLML VGAATTLIGS LGLLRLPDFY ARLHAPTIAT SGGTILLCLA
SILCFAVLQS RWVFHEVLII FFVTVTTPVT LMLLGQATLY RDRFEEQQGV PRKQKPAPGE
E
