ID   AST1_SCHPO              Reviewed;         519 AA.
AC   O14061;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 3.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Asteroid homolog 1;
GN   Name=ast1; ORFNames=SPCC962.05;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC       Mitochondrion {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the asteroid family. {ECO:0000305}.
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DR   EMBL; CU329672; CAA20437.2; -; Genomic_DNA.
DR   PIR; T41652; T41652.
DR   RefSeq; NP_587870.2; NM_001022862.3.
DR   AlphaFoldDB; O14061; -.
DR   BioGRID; 276048; 6.
DR   STRING; 4896.SPCC962.05.1; -.
DR   PaxDb; O14061; -.
DR   EnsemblFungi; SPCC962.05.1; SPCC962.05.1:pep; SPCC962.05.
DR   GeneID; 2539485; -.
DR   KEGG; spo:SPCC962.05; -.
DR   PomBase; SPCC962.05; ast1.
DR   VEuPathDB; FungiDB:SPCC962.05; -.
DR   HOGENOM; CLU_526930_0_0_1; -.
DR   InParanoid; O14061; -.
DR   OMA; LQAYANF; -.
DR   PRO; PR:O14061; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IC:PomBase.
DR   GO; GO:0035861; C:site of double-strand break; IDA:PomBase.
DR   GO; GO:0004518; F:nuclease activity; ISS:PomBase.
DR   GO; GO:0006281; P:DNA repair; ISM:PomBase.
DR   InterPro; IPR026832; Asteroid.
DR   InterPro; IPR039436; Asteroid_dom.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   PANTHER; PTHR15665; PTHR15665; 1.
DR   Pfam; PF12813; XPG_I_2; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Mitochondrion; Reference proteome.
FT   CHAIN           1..519
FT                   /note="Asteroid homolog 1"
FT                   /id="PRO_0000116536"
SQ   SEQUENCE   519 AA;  59951 MW;  28D7419E96C43D0F CRC64;
     MGVPRLGRFL EPFGKPVYFS SYPEVPLNCS LVIDGPSFAF WLWFSQGIVC SDFQGYQKAV
     LDFHHLLSRL RFKEIEYIFD GGLPFSKHQV RVNRYQQKIN DLRSAYINLC VPIAQHVLMG
     LAKAKVIVCN EEADKYCAFQ AKKLDAVILS QDSDFLLYDI DTPHYGYIPL QSLDVTSNGI
     SGRKYRFDEI QKDFHFDLHI LAAYLGVEGH PLDLVIDYHN TFEHICKILE NSVKDKFIEK
     LVSKEELTRV HAFYSLNDLK LETSTINTFM WGRVQELLNS QLQPAEIWLP QLLELPSKHC
     SWLESAPLRL QAYANFSKQM PEFGTEVLEY FRLSDRLSKR LISVDYDYAT VCETLDSKFS
     NWNLPHRLVL WTLRCMKNLN NITATSFLLM HVSLFLGSPM NLQPVEPTQE DIASVSRFIA
     TIYSICMLIF SEDKEQSSIS FQEFVSFSPL SSTLNFALFH QAASKLKTGK SPLSIVTDKT
     TASLTYKMYK DLTNDYSDIY MIMDIWKPKR KRKTKKDQS