ID   PHB1_DICDI              Reviewed;         271 AA.
AC   Q54GI9;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Prohibitin-1, mitochondrial;
DE   Flags: Precursor;
GN   Name=phbA; ORFNames=DDB_G0290123;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Prohibitin probably acts as a holdase/unfoldase for the
CC       stabilization of newly synthesized mitochondrial proteins.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Intermembrane side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the prohibitin family. {ECO:0000305}.
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DR   EMBL; AAFI02000153; EAL62378.1; -; Genomic_DNA.
DR   RefSeq; XP_635884.1; XM_630792.1.
DR   AlphaFoldDB; Q54GI9; -.
DR   SMR; Q54GI9; -.
DR   STRING; 44689.DDB0232063; -.
DR   PaxDb; Q54GI9; -.
DR   EnsemblProtists; EAL62378; EAL62378; DDB_G0290123.
DR   GeneID; 8627494; -.
DR   KEGG; ddi:DDB_G0290123; -.
DR   dictyBase; DDB_G0290123; phbA.
DR   eggNOG; KOG3083; Eukaryota.
DR   HOGENOM; CLU_047969_0_2_1; -.
DR   InParanoid; Q54GI9; -.
DR   OMA; SAIEHKQ; -.
DR   PhylomeDB; Q54GI9; -.
DR   Reactome; R-DDI-5673000; RAF activation.
DR   PRO; PR:Q54GI9; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR   CDD; cd03401; SPFH_prohibitin; 1.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR000163; Prohibitin.
DR   PANTHER; PTHR23222; PTHR23222; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   PRINTS; PR00679; PROHIBITIN.
DR   SMART; SM00244; PHB; 1.
DR   SUPFAM; SSF117892; SSF117892; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transit peptide.
FT   TRANSIT         1..24
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..271
FT                   /note="Prohibitin-1, mitochondrial"
FT                   /id="PRO_0000327658"
FT   COILED          201..221
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   271 AA;  30334 MW;  4723B30514644B7D CRC64;
     MQSFLNKLIP LALTVGTGLS LAQSSMYTVD GGQRAVIFDR ISGVKEKSVG EGTHFIMPWL
     QKPIIFDIRS SPRNIKSDTG SKDLQTVSVT VRVLFRPDVE HLPSIFSKLG LDYDERILPS
     LGNEVLKSVV AQYDATELIT QREVVSKEIR ESLMKRAKEF NLLLDDVSIT HLSFSQDFTN
     AIEHKQVAQQ EAERSKYIVM KNEQEKKANI IRAEGEAEAA KLIGQAMGNS AAFIELRRIE
     AYKDITESLS KSKQVTYVPT SGNLLMNLNK Q