ID   PHB7_ARATH              Reviewed;         278 AA.
AC   Q9FFH5;
DT   09-JAN-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Prohibitin-7, mitochondrial;
DE            Short=Atphb7;
GN   Name=PHB7; OrderedLocusNames=At5g44140; ORFNames=MLN1.6;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9330910; DOI=10.1093/dnares/4.3.215;
RA   Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M.,
RA   Miyajima N., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence
RT   features of the 1.6 Mb regions covered by twenty physically assigned P1
RT   clones.";
RL   DNA Res. 4:215-230(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP   ANALYSIS].
RC   STRAIN=cv. Landsberg erecta;
RX   PubMed=14671022; DOI=10.1105/tpc.016055;
RA   Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J.,
RA   Millar A.H.;
RT   "Experimental analysis of the Arabidopsis mitochondrial proteome highlights
RT   signaling and regulatory components, provides assessment of targeting
RT   prediction programs, and indicates plant-specific mitochondrial proteins.";
RL   Plant Cell 16:241-256(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, AND SUBUNIT.
RX   PubMed=18189341; DOI=10.1021/pr700595p;
RA   Meyer E.H., Taylor N.L., Millar A.H.;
RT   "Resolving and identifying protein components of plant mitochondrial
RT   respiratory complexes using three dimensions of gel electrophoresis.";
RL   J. Proteome Res. 7:786-794(2008).
CC   -!- FUNCTION: Prohibitin probably acts as a holdase/unfoldase for the
CC       stabilization of newly synthesized mitochondrial proteins.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of a prohibitin multimeric complex in mitochondrial
CC       membranes. {ECO:0000269|PubMed:18189341}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:18189341}; Single-pass
CC       type II membrane protein {ECO:0000269|PubMed:14671022,
CC       ECO:0000269|PubMed:18189341}.
CC   -!- SIMILARITY: Belongs to the prohibitin family. {ECO:0000305}.
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DR   EMBL; AB005239; BAB10981.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED95066.1; -; Genomic_DNA.
DR   RefSeq; NP_199227.1; NM_123781.2.
DR   AlphaFoldDB; Q9FFH5; -.
DR   SMR; Q9FFH5; -.
DR   BioGRID; 19687; 6.
DR   IntAct; Q9FFH5; 1.
DR   STRING; 3702.AT5G44140.1; -.
DR   PaxDb; Q9FFH5; -.
DR   PRIDE; Q9FFH5; -.
DR   ProteomicsDB; 236347; -.
DR   EnsemblPlants; AT5G44140.1; AT5G44140.1; AT5G44140.
DR   GeneID; 834437; -.
DR   Gramene; AT5G44140.1; AT5G44140.1; AT5G44140.
DR   KEGG; ath:AT5G44140; -.
DR   Araport; AT5G44140; -.
DR   TAIR; locus:2167588; AT5G44140.
DR   eggNOG; KOG3090; Eukaryota.
DR   HOGENOM; CLU_047969_0_2_1; -.
DR   InParanoid; Q9FFH5; -.
DR   OMA; YCIGSSM; -.
DR   OrthoDB; 1089994at2759; -.
DR   PhylomeDB; Q9FFH5; -.
DR   PRO; PR:Q9FFH5; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FFH5; baseline and differential.
DR   Genevisible; Q9FFH5; AT.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; HDA:TAIR.
DR   GO; GO:0005739; C:mitochondrion; IDA:TAIR.
DR   GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR   GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR   CDD; cd03401; SPFH_prohibitin; 1.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR000163; Prohibitin.
DR   PANTHER; PTHR23222; PTHR23222; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   PRINTS; PR00679; PROHIBITIN.
DR   SMART; SM00244; PHB; 1.
DR   SUPFAM; SSF117892; SSF117892; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..278
FT                   /note="Prohibitin-7, mitochondrial"
FT                   /id="PRO_0000420602"
FT   TOPO_DOM        1..14
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        15..37
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        38..278
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   COILED          186..220
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   278 AA;  30759 MW;  83281A247B5BD050 CRC64;
     MNVKKVPNVP GSPALSALLK LGVIGGLGLY CIGSSMYNVD GGHRAIVFNR FTGIKDRVYP
     EGTHFKIPLF ERAIIYDVRS RPYVENSQTG SNDLQTVTIG LRVLTRPMGD RLPEIYRTLG
     QNYGERVLPS IINETLKAVV AQYNASHLIT QREAVSREIR KIVTERAAKF NIALDDVSIT
     NLKFGKEFTE AIEKKQVAAQ EAERAKFIVE KAEQDKKSAI IRAQGEAKSA QLIGQAIANN
     EAFITLRKIE AAREIAQTIA KSANKVYLNS SDLLISKQ