ID   PHBS_MYCBO              Reviewed;         199 AA.
AC   Q7TXK6; A0A1R3Y4M7; X2BMN6;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Chorismate pyruvate-lyase;
DE            EC=4.1.3.40;
DE   AltName: Full=4-HB synthase;
DE   AltName: Full=p-hydroxybenzoic acid synthase;
GN   OrderedLocusNames=BQ2027_MB2973C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Removes the pyruvyl group from chorismate to provide 4-
CC       hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p-
CC       hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids
CC       (PGL) that play important roles in the pathogenesis of mycobacterial
CC       infections (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=chorismate = 4-hydroxybenzoate + pyruvate;
CC         Xref=Rhea:RHEA:16505, ChEBI:CHEBI:15361, ChEBI:CHEBI:17879,
CC         ChEBI:CHEBI:29748; EC=4.1.3.40;
CC   -!- SIMILARITY: Belongs to the chorismate pyruvate-lyase type 2 family.
CC       {ECO:0000305}.
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DR   EMBL; LT708304; SIU01595.1; -; Genomic_DNA.
DR   RefSeq; NP_856618.1; NC_002945.3.
DR   RefSeq; WP_003414887.1; NC_002945.4.
DR   AlphaFoldDB; Q7TXK6; -.
DR   SMR; Q7TXK6; -.
DR   EnsemblBacteria; SIU01595; SIU01595; BQ2027_MB2973C.
DR   GeneID; 45426934; -.
DR   PATRIC; fig|233413.5.peg.3265; -.
DR   OMA; VIIITEY; -.
DR   BioCyc; MetaCyc:MON-19636; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0008813; F:chorismate lyase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.1410.10; -; 1.
DR   InterPro; IPR028978; Chorismate_lyase_/UTRA_dom_sf.
DR   InterPro; IPR002800; Rv2949c-like.
DR   Pfam; PF01947; DUF98; 1.
DR   SUPFAM; SSF64288; SSF64288; 1.
PE   3: Inferred from homology;
KW   Lyase.
FT   CHAIN           1..199
FT                   /note="Chorismate pyruvate-lyase"
FT                   /id="PRO_0000240508"
SQ   SEQUENCE   199 AA;  22587 MW;  889D7554EA82A18B CRC64;
     MTECFLSDQE IRKLNRDLRI LIAANGTLTR VLNIVADDEV IVQIVKQRIH DVSPKLSEFE
     QLGQVGVGRV LQRYIILKGR NSEHLFVAAE SLIAIDRLPA AIITRLTQTN DPLGEVMAAS
     HIETFKEEAK VWVGDLPGWL ALHGYQNSRK RAVARRYRVI SGGQPIMVVT EHFLRSVFRD
     APHEEPDRWQ FSNAITLAR