ID   PHBS_MYCTO              Reviewed;         199 AA.
AC   P9WIC4; L0TDV5; O86325; Q7D6D8;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Chorismate pyruvate-lyase;
DE            EC=4.1.3.40;
DE   AltName: Full=4-HB synthase;
DE   AltName: Full=p-hydroxybenzoic acid synthase;
GN   OrderedLocusNames=MT3022;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Removes the pyruvyl group from chorismate to provide 4-
CC       hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p-
CC       hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids
CC       (PGL) that play important roles in the pathogenesis of mycobacterial
CC       infections (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=chorismate = 4-hydroxybenzoate + pyruvate;
CC         Xref=Rhea:RHEA:16505, ChEBI:CHEBI:15361, ChEBI:CHEBI:17879,
CC         ChEBI:CHEBI:29748; EC=4.1.3.40;
CC   -!- SIMILARITY: Belongs to the chorismate pyruvate-lyase type 2 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK47348.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK47348.1; ALT_INIT; Genomic_DNA.
DR   PIR; B70669; B70669.
DR   RefSeq; WP_003414887.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WIC4; -.
DR   SMR; P9WIC4; -.
DR   EnsemblBacteria; AAK47348; AAK47348; MT3022.
DR   GeneID; 45426934; -.
DR   KEGG; mtc:MT3022; -.
DR   HOGENOM; CLU_107938_1_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0008813; F:chorismate lyase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.1410.10; -; 1.
DR   InterPro; IPR028978; Chorismate_lyase_/UTRA_dom_sf.
DR   InterPro; IPR002800; Rv2949c-like.
DR   Pfam; PF01947; DUF98; 1.
DR   SUPFAM; SSF64288; SSF64288; 1.
PE   3: Inferred from homology;
KW   Lyase.
FT   CHAIN           1..199
FT                   /note="Chorismate pyruvate-lyase"
FT                   /id="PRO_0000428031"
SQ   SEQUENCE   199 AA;  22587 MW;  889D7554EA82A18B CRC64;
     MTECFLSDQE IRKLNRDLRI LIAANGTLTR VLNIVADDEV IVQIVKQRIH DVSPKLSEFE
     QLGQVGVGRV LQRYIILKGR NSEHLFVAAE SLIAIDRLPA AIITRLTQTN DPLGEVMAAS
     HIETFKEEAK VWVGDLPGWL ALHGYQNSRK RAVARRYRVI SGGQPIMVVT EHFLRSVFRD
     APHEEPDRWQ FSNAITLAR