ID   ASTAE_ASTSM             Reviewed;          36 AA.
AC   P84702;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Asteropin-A;
DE   AltName: Full=Asteropine-A;
OS   Asteropus simplex (Marine sponge) (Stellettinopsis simplex).
OC   Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC   Tetractinellida; Astrophorina; Ancorinidae; Asteropus.
OX   NCBI_TaxID=350939;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, STRUCTURE BY NMR, AND
RP   DISULFIDE BONDS.
RX   PubMed=16793514; DOI=10.1016/j.chembiol.2006.05.010;
RA   Takada K., Hamada T., Hirota H., Nakao Y., Matsunaga S., van Soest R.W.M.,
RA   Fusetani N.;
RT   "Asteropine A, a sialidase-inhibiting conotoxin-like peptide from the
RT   marine sponge Asteropus simplex.";
RL   Chem. Biol. 13:569-574(2006).
CC   -!- FUNCTION: Sialidase inhibitor. Competitively inhibits bacterial
CC       sialidases, but not viral sialidases. Does not inhibit glycosidases or
CC       proteases. Has no antitumor activity. {ECO:0000269|PubMed:16793514}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC   -!- MASS SPECTROMETRY: Mass=3817.5; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16793514};
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DR   AlphaFoldDB; P84702; -.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Knottin.
FT   PEPTIDE         1..36
FT                   /note="Asteropin-A"
FT                   /id="PRO_0000249178"
FT   DISULFID        2..18
FT                   /evidence="ECO:0000269|PubMed:16793514"
FT   DISULFID        9..25
FT                   /evidence="ECO:0000269|PubMed:16793514"
FT   DISULFID        17..35
FT                   /evidence="ECO:0000269|PubMed:16793514"
SQ   SEQUENCE   36 AA;  3826 MW;  76ADFF7291812EEC CRC64;
     YCGLFGDLCT LDGTLACCIA LELECIPLND FVGICL