ID   PHC2_XENLA              Reviewed;         344 AA.
AC   Q4V7W5;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Polyhomeotic-like protein 2;
GN   Name=phc2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like
CC       complex, a complex class required to maintain the transcriptionally
CC       repressive state of many genes, including Hox genes, throughout
CC       development. PcG PRC1 complex acts via chromatin remodeling and
CC       modification of histones; it mediates monoubiquitination of histone H2A
CC       'Lys-119', rendering chromatin heritably changed in its expressibility
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of a PRC1-like complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; BC097691; AAH97691.1; -; mRNA.
DR   RefSeq; NP_001089479.1; NM_001096010.1.
DR   RefSeq; XP_018097321.1; XM_018241832.1.
DR   RefSeq; XP_018097322.1; XM_018241833.1.
DR   AlphaFoldDB; Q4V7W5; -.
DR   SMR; Q4V7W5; -.
DR   DNASU; 734530; -.
DR   GeneID; 734530; -.
DR   KEGG; xla:734530; -.
DR   CTD; 734530; -.
DR   Xenbase; XB-GENE-997001; phc2.L.
DR   OrthoDB; 298184at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 734530; Expressed in oocyte and 11 other tissues.
DR   GO; GO:0031519; C:PcG protein complex; ISS:UniProtKB.
DR   GO; GO:0035102; C:PRC1 complex; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.150.50; -; 1.
DR   Gene3D; 3.30.60.160; -; 1.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR012313; Znf_FCS.
DR   InterPro; IPR038603; Znf_FCS_sf.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
DR   PROSITE; PS51024; ZF_FCS; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..344
FT                   /note="Polyhomeotic-like protein 2"
FT                   /id="PRO_0000076289"
FT   DOMAIN          280..344
FT                   /note="SAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT   ZN_FING         114..148
FT                   /note="FCS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00367"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          165..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           25..53
FT                   /note="HD1"
FT   COMPBIAS        1..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..252
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         123
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00367"
FT   BINDING         126
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00367"
FT   BINDING         142
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00367"
FT   BINDING         146
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00367"
SQ   SEQUENCE   344 AA;  37932 MW;  1FFB6C62686C85D2 CRC64;
     MTSGNGSSPV PTAATGNRTQ NGENKPPQAV VKPQILTHFI EGFVIQEGAQ PFPSHRSRAV
     LEVGHSSLLT GAQEKYQQSL LAEKVPQQDN NTTTTTTDSE MEETLVPGFP ESKGDGDPPK
     LKCELCGRVD FEYKFKRSKR FCSMACAKRY NVGCTKRVGL FHPDRSKLQK PTVAKHARRR
     SRKTPLQTVG ADPKKQQAAP VTPMNPGPIP SPSALKLSNS QEDSSRCSDN SSYEEPLSPM
     SASSSLSRAR QEHNVEPPNL HSRDPIAMSQ DFLPSDPTKW NVEDVYDFVR SLPGCQEISE
     EFRAQEIDGQ ALLLLKEDHL MSAMNIKLGP ALKLYARISM LKDS